Academic Journal
Naringenin Reduces Hepatic Inflammation and Apoptosis Induced by Vancomycin in Rats
| العنوان: | Naringenin Reduces Hepatic Inflammation and Apoptosis Induced by Vancomycin in Rats |
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| المؤلفون: | UÇKUN ŞAHİNOĞULLARI, Zuhal, GÜZEL, Sevda, CANACANKATAN, Necmiye, YALAZA, Cem, KİBAR, Deniz, BAYRAK, Gulsen |
| المصدر: | Volume: 11, Issue: 2 191-198 ; 2459-1459 ; Clinical and Experimental Health Sciences |
| بيانات النشر: | Marmara Üniversitesi Marmara University |
| سنة النشر: | 2021 |
| المجموعة: | DergiPark Akademik (E-Journals) |
| مصطلحات موضوعية: | Vancomycin,Naringenin,Liver,Apoptosis,Inflammation |
| الوصف: | Objective: This investigation aimed to detect the possible protective impacts of naringenin (NAR) on vancomycin (VCM)-induced liver toxicity through measuring caspase-3, -8 and -9 activities as markers of apoptosis and the levels of tumor necrosis factor-alpha, cyclooxygenase-2 and vascular endothelial growth factor as inflammation markers and assessing the histopathological alterations in rats. Methods: The rats were allocated into seven groups as, the control group (saline, intraperitoneally (i.p.)), VCM group (400 mg/kg/day, i.p.), Carboxymethyl cellulose group (0.5% CMC, orally), NAR100 group (100 mg/kg/day, orally), VCM+NAR25 group (25 mg/kg/day, orally), VCM+NAR50 group (50 mg/kg/day, orally), VCM+NAR100 group (100 mg/kg/day, orally). The caspase enzyme activities and inflammation markers were measured using colorimetric methods and ELISA, respectively. Histopathological examinations were performed. Results: The caspase activities and levels of inflammation markers were significantly higher in the VCM group as opposed to the other groups. The caspase activities were significantly ameliorated in the VCM+NAR25 group compared to the VCM+NAR50 and VCM+NAR100 groups, but the levels of inflammation markers were significantly attenuated in VCM+NAR50 group and, especially, VCM+NAR100 group compared to VCM+NAR25 group. Conclusion: NAR has potential protective impact on liver injury caused by VCM, and the protective impacts of NAR at distinct doses may occur via different molecular mechanisms. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://dergipark.org.tr/tr/download/article-file/1117185; https://dergipark.org.tr/tr/pub/clinexphealthsci/issue/62013/741916 |
| DOI: | 10.33808/clinexphealthsci.741916 |
| الاتاحة: | https://dergipark.org.tr/tr/pub/clinexphealthsci/issue/62013/741916 https://doi.org/10.33808/clinexphealthsci.741916 |
| رقم الانضمام: | edsbas.EA99F29A |
| قاعدة البيانات: | BASE |
| DOI: | 10.33808/clinexphealthsci.741916 |
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