التفاصيل البيبلوغرافية
| العنوان: |
Assessment of in vivo estrogenic and anti-inflammatory activities of the hydro-ethanolic extract and polyphenolic fraction of parsley (Petroselinum sativum Hoffm.) |
| المؤلفون: |
Slighoua, Meryem, Mahdi, Ismail, Amrati, Fatima ez-Zahra, Di Cristo, Francesca, Amaghnouje, Amal, Grafov, Andrey, Boucetta, Nabil, Bari, Amina, Bousta, Dalila |
| المساهمون: |
Department of Chemistry, Materials Chemistry |
| بيانات النشر: |
ELSEVIER IRELAND LTD |
| سنة النشر: |
2022 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
Petroselinum sativum Hoffm, Sub-acute toxicity, Histopathological examination, Anti-inflammatory activity, Estrogenic effect, FEMALE, QUANTIFICATION, IDENTIFICATION, CHOLESTEROL, METABOLISM, FLAVONOIDS, PARAMETERS, MECHANISM, CRISPUM, LEAVES, Pharmacy, Chemical sciences |
| الوصف: |
Ethnopharmacological relevance: Since the dawn of time, medicinal and aromatic plants (AMPs) represent a precious heritage for humanity, especially in developing countries, who exploit their virtues in traditional pharmacopoeia to cope with health problems such as diabetes, kidney stones, ulcer, and digestive disorders. Petroselinum sativum Hoffm. belongs to Apiaceae family. It is traditionally used to treat arterial hypertension, diabetes, cardiac disease, renal disease, and recently reported as a plant endowed with a female anti-infertility effect. Aim of the study: This study aims to evaluate the in vivo effect of hydro-ethanolic extract and polyphenols of Petroselinum sativum Hoffm. on cholesterol, protein and estrogen levels, and characterize the chemical composition of polyphenolic fraction. In addition, acute toxicity and anti-inflammatory activity of tested extract was also investigated. Materials and methods: Chemical composition of polyphenolic fraction was determined using High-Performance Liquid Chromatography with Diode-Array Detection (HPLC-DAD). First, toxicological investigations including sub-acute toxicity were performed by measuring animals' weights daily for four weeks. Afterwards, histopathological examination of livers and kidneys, and serum assay of ASAT and ALAT were also checked. Next, the acute in vivo anti-inflammatory study of the hydro-ethanolic extract and polyphenols of Petroselinum sativum Hoffm. versus Indomethacin was conducted. Furthermore, we evaluated the estrogenic effect of its hydroethanolic extract and the polyphenolic fraction following biochemical assays for the determination of proteins, cholesterol and estrogen levels. Results: The results revealed the presence of some phenolic compounds mainly ferulic acid, gallic acid and quercetin. Petroselinum sativum Hoffm. extracts also showed no evidence of hepatotoxicity nor nephrotoxicity, with remarkable anti-inflammatory activity, as well as a significant estrogenic effect compared to negative control. Conclusion: This ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
We would like to extend our sincere thanks to the project H2020MSCA-RISE-Marie Sklodowska-Curie Actions (MSCA) Research and innovation Staff Exchange (RISE) for funding this work, Project Acronym: VAHVISTUS-Project Number: 734759.; Slighoua , M , Mahdi , I , Amrati , F E-Z , Di Cristo , F , Amaghnouje , A , Grafov , A , Boucetta , N , Bari , A & Bousta , D 2021 , ' Assessment of in vivo estrogenic and anti-inflammatory activities of the hydro-ethanolic extract and polyphenolic fraction of parsley (Petroselinum sativum Hoffm.) ' , Journal of Ethnopharmacology , vol. 265 , 113290 . https://doi.org/10.1016/j.jep.2020.113290; ORCID: /0000-0002-7387-3676/work/99763069; http://hdl.handle.net/10138/340843; 31c777ec-6c4b-4ee6-8e64-37dddeb6e9b2; 000583286600024 |
| الاتاحة: |
http://hdl.handle.net/10138/340843 |
| Rights: |
cc_by_nc_nd ; info:eu-repo/semantics/openAccess ; openAccess |
| رقم الانضمام: |
edsbas.EA8ABCC5 |
| قاعدة البيانات: |
BASE |