Academic Journal
PLOS ONE / Transfusion of standard-issue packed red blood cells induces pulmonary vasoconstriction in critically ill patients after cardiac surgery—A randomized, double-blinded, clinical trial
| العنوان: | PLOS ONE / Transfusion of standard-issue packed red blood cells induces pulmonary vasoconstriction in critically ill patients after cardiac surgery—A randomized, double-blinded, clinical trial |
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| المؤلفون: | Baron, David M., Baron-Stefaniak, Joanna, Leitner, Gerda C., Küntzel, Nina K. I., Meyer, Elias L., Hiesmayr, Michael J., Ullrich, Roman |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2019 |
| المجموعة: | MedUni Vienna ePub (Medzinische Universität Wien) |
| جغرافية الموضوع: | UMW:14533, UMW:14615, UMW:14603 |
| الوصف: | Background Experimental and volunteer studies have reported pulmonary vasoconstriction during transfusion of packed red blood cells (PRBCs) stored for prolonged periods. The primary aim of this study was to evaluate whether transfusion of PRBCs stored over 21 days (standard-issue, siPRBCs) increases pulmonary artery pressure (PAP) to a greater extent than transfusion of PRBCs stored for less then 14 days (fresh, fPRBCs) in critically ill patients following cardiac surgery. The key secondary aim was to assess whether the pulmonary vascular resistance index (PVRI) increases after transfusion of siPRBCs to a greater extent than after transfusion of fPRBCs. Methods The study was performed as a single-center, double-blinded, parallel-group, randomized clinical trial. Leukoreduced PRBCs were transfused while continuously measuring hemodynamic parameters. Systemic concentrations of syndecan-1 were measured to assess glycocalyx injury. After randomizing 19 patients between January 2014 and June 2016, the study was stopped due to protracted patient recruitment. Results Of 19 randomized patients, 11 patients were transfused and included in statistical analyses. Eight patients were excluded prior to transfusion, 6 patients received fPRBCs (10±3 storage days), whereas 5 patients received siPRBCs (33±4 storage days). The increase in PAP (7±3 vs. 2±2 mmHg, P = 0.012) was greater during transfusion of siPRBCs than during transfusion of fPRBCs. In addition, the change in PVRI (150±89 vs. -4±37 dyn·s·cm⁻⁵·m², P = 0.018) was greater after transfusion of siPRBCs than after transfusion of fPRBCs. The increase in PAP correlated with the change of systemic syndecan-1 concentrations at the end of transfusion (R = 0.64,P = 0.034). Conclusion Although this study is underpowered and results require verification in larger clinical trials, our findings suggest that transfusion of siPRBCs increases PAP and PVRI to a greater extent than transfusion of fPRBCs in critically ill patients following cardiac surgery. Glycocalyx injury might ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | vignette : https://repositorium.meduniwien.ac.at/titlepage/urn/urn:nbn:at:at-ubmuw:3-22044/128; urn:nbn:at:at-ubmuw:3-22044; https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-22044; local:99145437007203331; system:AC15649401 |
| DOI: | 10.1371/journal.pone.0213000 |
| الاتاحة: | https://resolver.obvsg.at/urn:nbn:at:at-ubmuw:3-22044 https://doi.org/10.1371/journal.pone.0213000 https://repositorium.meduniwien.ac.at/doi/10.1371/journal.pone.0213000 |
| Rights: | cc-by_4 |
| رقم الانضمام: | edsbas.EA84764C |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0213000 |