Academic Journal
Preeclampsia may influence offspring neuroanatomy and cognitive function: a role for placental growth factor†
| العنوان: | Preeclampsia may influence offspring neuroanatomy and cognitive function: a role for placental growth factor† |
|---|---|
| المؤلفون: | Kay, Vanessa R, Rätsep, Matthew T, Figueiró-Filho, Ernesto A, Croy, B Anne |
| المساهمون: | Kingston General Hospital |
| المصدر: | Biology of Reproduction ; volume 101, issue 2, page 271-283 ; ISSN 0006-3363 1529-7268 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2019 |
| الوصف: | Preeclampsia (PE) is a common pregnancy complication affecting 3–5% of women. Preeclampsia is diagnosed clinically as new-onset hypertension with associated end organ damage after 20 weeks of gestation. Despite being diagnosed as a maternal syndrome, fetal experience of PE is a developmental insult with lifelong cognitive consequences. These cognitive alterations are associated with distorted neuroanatomy and cerebrovasculature, including a higher risk of stroke. The pathophysiology of a PE pregnancy is complex, with many factors potentially able to affect fetal development. Deficient pro-angiogenic factor expression is one aspect that may impair fetal vascularization, alter brain structure, and affect future cognition. Of the pro-angiogenic growth factors, placental growth factor (PGF) is strongly linked to PE. Concentrations of PGF are inappropriately low in maternal blood both before and during a PE gestation. Fetal concentrations of PGF appear to mirror maternal circulating concentrations. Using Pgf−/− mice that may model effects of PE on offspring, we demonstrated altered central nervous system vascularization, neuroanatomy, and behavior. Overall, we propose that development of the fetal brain is impaired in PE, making the offspring of preeclamptic pregnancies a unique cohort with greater risk of altered cognition and cerebrovasculature. These individuals may benefit from early interventions, either pharmacological or environmental. The early neonatal period may be a promising window for intervention while the developing brain retains plasticity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/biolre/ioz095 |
| DOI: | 10.1093/biolre/ioz095/28905711/ioz095.pdf |
| الاتاحة: | https://doi.org/10.1093/biolre/ioz095 http://academic.oup.com/biolreprod/advance-article-pdf/doi/10.1093/biolre/ioz095/28905711/ioz095.pdf http://academic.oup.com/biolreprod/article-pdf/101/2/271/29208462/ioz095.pdf |
| Rights: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| رقم الانضمام: | edsbas.EA76D2C0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/biolre/ioz095 |
|---|