Academic Journal
During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities.
| العنوان: | During the early prediabetic period in NOD mice, the pathogenic CD8(+) T-cell population comprises multiple antigenic specificities. |
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| المؤلفون: | DiLorenzo, T P, Lieberman, S M, Takaki, T, Honda, S, Chapman, H D, Santamaria, P, Serreze, D V, Nathenson, S G |
| المصدر: | Faculty Research 2000 - 2009 |
| بيانات النشر: | The Mouseion at the JAXlibrary |
| سنة النشر: | 2002 |
| المجموعة: | The Jackson Laboratory: The Mouseion at the JAXlibrary |
| مصطلحات موضوعية: | CD8-Positive-T-Lymphocytes, Cell-Line-Transformed, Clone-Cells, Diabetes-Mellitus-Insulin-Dependent, Epitopes, Histocompatibility-Antigens-Class-I, Insulin, Islets-of-Langerhans, Mice, Mice-Inbred-NOD, Mice-Transgenic, Prediabetic-State, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, T-Lymphocytes-Cytotoxic |
| الوصف: | In the NOD mouse model of type 1 diabetes, major histocompatibilitycomplex (MHC) class I-restricted CD8(+) T cells are essential for disease development. However, the extent of diversity of their antigenic specificities during early pathogenesis remains unclear. An insulin-derived peptide was recently identified as the epitope for the NOD-derived diabetogenic T-cell clone G9C8. To explore the possibility that the early pathogenic CD8(+) T-cell population comprises additional antigenic specificities, we employed the T-cell clones AI4 and NY8.3, both of which are pathogenic and represent specificities present in early insulitic lesions. The clones responded to distinct fractions of chromatographically separated class I MHC-bound peptides purified from NOD-derived NIT-1 beta cells, and neither clone recognized the insulin-derived peptide. NIT-1 cells represent an unlimited peptide source that will allow for the future isolation and sequencing of the novel multiple epitopes targeted early in the autoimmune response by pathogenic CD8(+) T cells. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| Relation: | https://mouseion.jax.org/stfb2000_2009/450; http://linkinghub.elsevier.com/retrieve/pii/S1521661602952988 |
| الاتاحة: | https://mouseion.jax.org/stfb2000_2009/450 http://linkinghub.elsevier.com/retrieve/pii/S1521661602952988 |
| رقم الانضمام: | edsbas.EA70FBBC |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |