Academic Journal
Re-polarisation of macrophages within collective tumour cell migration:a multiscale moving boundary approach
| العنوان: | Re-polarisation of macrophages within collective tumour cell migration:a multiscale moving boundary approach |
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| المؤلفون: | Suveges, Szabolcs, Eftimie, Raluca, Trucu, Dumitru |
| المصدر: | Suveges , S , Eftimie , R & Trucu , D 2022 , ' Re-polarisation of macrophages within collective tumour cell migration : a multiscale moving boundary approach ' , Frontiers in Applied Mathematics and Statistics , vol. 7 , 799650 . https://doi.org/10.3389/fams.2021.799650 |
| سنة النشر: | 2022 |
| المجموعة: | Discovery - University of Dundee Online Publications |
| مصطلحات موضوعية: | Collective Cancer Cell Movement, cancer invasion, Macrophages, Macrophage re-polarisation, Multi-scale modelling, Cell adhesions, WENO schemes, Convolution, /dk/atira/pure/subjectarea/asjc/2600/2604, name=Applied Mathematics, /dk/atira/pure/subjectarea/asjc/2600/2613, name=Statistics and Probability |
| الوصف: | Cancer invasion of the surrounding tissue is a multiscale process of collective cell movement that involves not only tumour cells but also other immune cells in the environment, such as the tumour-associated macrophages (TAMs). The heterogeneity of these immune cells, with the two extremes being the pro-inflammatory and anti-tumour M1 cells, and the anti-inflammatory and pro-tumour M2 cells, has a significant impact on cancer invasion as these cells interact in different ways with the tumour cells and with the ExtraCellular Matrix (ECM). Experimental studies have shown that cancer cells co-migrate with TAMs, but the impact of these different TAM sub-populations (which can change their phenotype and re-polarise depending on the microenvironment) on this co-migration is not fully understood. In this study, we extend a previous multi-scale moving boundary mathematical model, by introducing the M1-like macrophages alongside with their exerted multi-scale effects on the tumour invasion process. With the help of this model we investigate numerically the impact of re-polarising the M2 TAMs into the anti-tumoral M1 phenotype and how such a strategy affects the overall tumour progression. In particular, we investigate numerically whether the M2→M1 re-polarisation could depend on time and/or space, and what would be the macroscopic effects of this spatial- and temporal-dependent re-polarisation on tumour invasion. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.3389/fams.2021.799650 |
| الاتاحة: | https://discovery.dundee.ac.uk/en/publications/3ece53b3-d9e4-4e98-834f-756cb264376a https://doi.org/10.3389/fams.2021.799650 https://discovery.dundee.ac.uk/ws/files/71611419/fams_07_799650.pdf http://www.scopus.com/inward/record.url?scp=85124617128&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.EA331BDB |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fams.2021.799650 |
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