Academic Journal
Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice
| العنوان: | Gallic acid improves glucose tolerance and triglyceride concentration in diet-induced obesity mice |
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| المساهمون: | Eun-Jung Bak, Jinmoon Kim, Sungil Jang, Gye-Hyeong Woo, Ho-Geun Yoon, Yun-Jung Yoo, Jeong-Heon Cha Read More: http://informahealthcare.com/doi/abs/10.3109/00365513.2013.831470, Kim, Jin Moon, Bak, Eun-Jung, Yoo, Yun Jung, Yoon, Ho Geun, Jang, Sung Il, Cha, Jung Heon, Jang, Sungil |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adipose Tissue, White/drug effects, White/metabolism, Animals, Blood Glucose/drug effects, Body Weight, Eating/drug effects, Gallic Acid/adverse effects, Gallic Acid/metabolism, Gallic Acid/pharmacology, Glucose Intolerance/drug therapy, Glucose Tolerance Test, Insulin/blood, Insulin/metabolism, Lipid Metabolism/drug effects, Lipid Metabolism/physiology, Liver/drug effects, Liver/metabolism, Male, Mice, Inbred C57BL, Obese, PPAR gamma/metabolism, Phosphorylation/drug effects, Proto-Oncogene Proteins c-akt/metabolism, Triglycerides/blood, Triglycerides/metabolism, Gallic acid, diet-induced obesity mice, glucose tolerance |
| الوصف: | Gallic acid, a phenolic phytochemical, has been shown to exert a variety of effects, including anti-oxidative, anti- carcinogenic, anti-allergic, and anti-inflammatory effects. In this study, we attempted to determine whether gallic acid affects metabolic syndrome such as obesity and diabetes. Diet-induced obesity mice were treated intraperitoneally once per day with gallic acid (10 mg/kg/day). After 2 weeks of treatment, the mice were sacrificed to collect the blood for metabolic parameter assessments, and the adipose tissues and liver to weigh and analyze. The triglyceride concentrations were significantly improved in the gallic acid group relative to those measured in the control group. And most importantly, the blood glucose concentrations in the gallic acid group were significantly improved. In the epididymal white adipose tissue of the gallic acid group, adipocyte size was reduced, PPAR款 expression was induced, and the Akt signaling pathway was activated. Our results demonstrate that gallic acid improves glucose tolerance and lipid metabolism in the obesity mice, thereby showing evidence of anti-hyperglycemic activity. The findings of an upregulation of PPAR款 expression and Akt activation also contribute to our current understanding of the mechanisms underlying the effects of gallic acid on glucose metabolism. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 0036-5513 1502-7686 24219649 |
| Relation: | SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION; J02631; OAK-2013-02682; https://ir.ymlib.yonsei.ac.kr/handle/22282913/88798; T201305154; SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION, Vol.73(8) : 607-614, 2013 |
| DOI: | 10.3109/00365513.2013.831470 |
| الاتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/88798 https://doi.org/10.3109/00365513.2013.831470 http://informahealthcare.com/doi/abs/10.3109/00365513.2013.831470 |
| Rights: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ ; not free |
| رقم الانضمام: | edsbas.EA1B5EAB |
| قاعدة البيانات: | BASE |
| تدمد: | 00365513 15027686 24219649 |
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| DOI: | 10.3109/00365513.2013.831470 |