Identifying Cattle Breed-Specific Partner Choice of Transcription Factors during the African Trypanosomiasis Disease Progression Using Bioinformatics Analysis

التفاصيل البيبلوغرافية
العنوان:	Identifying Cattle Breed-Specific Partner Choice of Transcription Factors during the African Trypanosomiasis Disease Progression Using Bioinformatics Analysis
المؤلفون:	Abirami Rajavel, Felix Heinrich, Armin Otto Schmitt, Mehmet Gültas
المصدر:	Vaccines, Vol 8, Iss 246, p 246 (2020)
بيانات النشر:	MDPI AG
سنة النشر:	2020
المجموعة:	Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية:	Animal African Trypanosomiasis, Boran, N’Dama, trypanotolerance, susceptibility, PC-TraFF, Medicine
الوصف:	African Animal Trypanosomiasis (AAT) is a disease caused by pathogenic trypanosomes which affects millions of livestock every year causing huge economic losses in agricultural production especially in sub-Saharan Africa. The disease is spread by the tsetse fly which carries the parasite in its saliva. During the disease progression, the cattle are prominently subjected to anaemia, weight loss, intermittent fever, chills, neuronal degeneration, congestive heart failure, and finally death. According to their different genetic programs governing the level of tolerance to AAT, cattle breeds are classified as either resistant or susceptible. In this study, we focus on the cattle breeds N’Dama and Boran which are known to be resistant and susceptible to trypanosomiasis, respectively. Despite the rich literature on both breeds, the gene regulatory mechanisms of the underlying biological processes for their resistance and susceptibility have not been extensively studied. To address the limited knowledge about the tissue-specific transcription factor (TF) cooperations associated with trypanosomiasis, we investigated gene expression data from these cattle breeds computationally. Consequently, we identified significant cooperative TF pairs (especially D B P − P P A R A and D B P − T H A P 1 in N’Dama and D B P − P A X 8 in Boran liver tissue) which could help understand the underlying AAT tolerance/susceptibility mechanism in both cattle breeds.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
تدمد:	2076-393X
Relation:	https://www.mdpi.com/2076-393X/8/2/246; https://doaj.org/toc/2076-393X; https://doaj.org/article/c93dbbd04d374495b39ea00fc5051a6c
DOI:	10.3390/vaccines8020246
الاتاحة:	https://doi.org/10.3390/vaccines8020246 https://doaj.org/article/c93dbbd04d374495b39ea00fc5051a6c
رقم الانضمام:	edsbas.E9DB5E4A
قاعدة البيانات:	BASE

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الوصف
تدمد:	2076393X
DOI:	10.3390/vaccines8020246