Academic Journal
The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health
| العنوان: | The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health |
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| المؤلفون: | Roblin, Clarisse, Chiumento, Steve, Jacqueline, Cédric, Pinloche, Eric, Nicoletti, Cendrine, Olleik, Hamza, Courvoisier-Dezord, Elise, Amouric, Agnès, Basset, Christian, Dru, Louis, Ollivier, Marie, Bogey-Lambert, Aurélie, Vidal, Nicolas, Atta, Mohamed, Maresca, Marc, Devillard, Estelle, Duarte, Victor, Perrier, Josette, Lafond, Mickael |
| المساهمون: | Institut des Sciences Moléculaires de Marseille (ISM2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), ADISSEO France SAS, Centre d’Expertise et de Recherche en Nutrition, Biocatalyse (BIOCAT), Laboratoire de Chimie et Biologie des Métaux (LCBM - UMR 5249), Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Thérapeutiques cliniques et expérimentales des infections (EA 3826) (EA 3826), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), BioAzur Biogroup-Vet’Analys Laboratory, Institut de Chimie Radicalaire (ICR), Aix Marseille Université (AMU)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), ANR-15-CE21-0020,RUMBA,Caractérisations structurale et fonctionnelle de la Biosynthèse des peptides RumC : une nouvelle famille de bactériocines comme alternative viable aux antibiotiques conventionnels.(2015), ANR-20-CE44-0021,RUMisBAC,Mode d'action et bio-ingénierie des sactipeptides RumC pour vaincre la résistance aux antibiotiques des bactéries à Gram-positif(2020), ANR-10-INBS-0008,ProFI,Infrastructure Française de Protéomique(2010), ANR-17-EURE-0003,CBH-EUR-GS,CBH-EUR-GS(2017) |
| المصدر: | ISSN: 1661-6596. |
| بيانات النشر: | CCSD MDPI |
| سنة النشر: | 2021 |
| المجموعة: | Université de Nantes: HAL-UNIV-NANTES |
| مصطلحات موضوعية: | antibiotics, antimicrobial resistance, RiPP, sactipeptide, Ruminococcus gnavus E1, peritonitis infection, microbiome, Clostridium perfringens, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology |
| الوصف: | International audience ; The world is on the verge of a major antibiotic crisis as the emergence of resistant bacteria is increasing, and very few novel molecules have been discovered since the 1960s. In this context, scientists have been exploring alternatives to conventional antibiotics, such as ribosomally synthesized and post-translationally modified peptides (RiPPs). Interestingly, the highly potent in vitro antibacterial activity and safety of ruminococcin C1, a recently discovered RiPP belonging to the sactipeptide subclass, has been demonstrated. The present results show that ruminococcin C1 is efficient at curing infection and at protecting challenged mice from Clostridium perfringens with a lower dose than the conventional antibiotic vancomycin. Moreover, antimicrobial peptide (AMP) is also effective against this pathogen in the complex microbial community of the gut environment, with a selective impact on a few bacterial genera, while maintaining a global homeostasis of the microbiome. In addition, ruminococcin C1 exhibits other biological activities that could be beneficial for human health, as well as other fields of applications. Overall, this study, by using an in vivo infection approach, confirms the antimicrobial clinical potential and highlights the multiple functional properties of ruminococcin C1, thus extending its therapeutic interest. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.3390/ijms22063253 |
| الاتاحة: | https://hal.science/hal-03232443 https://hal.science/hal-03232443v1/document https://hal.science/hal-03232443v1/file/ijms-22-03253.pdf https://doi.org/10.3390/ijms22063253 |
| Rights: | http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.E9CED4F |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms22063253 |
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