Academic Journal
Neurocognitive and social-communicative function of children born very preterm at 10 years of age: Associations with microorganisms recovered from the placenta parenchyma
| العنوان: | Neurocognitive and social-communicative function of children born very preterm at 10 years of age: Associations with microorganisms recovered from the placenta parenchyma |
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| المؤلفون: | Tomlinson, Martha Scott, Santos, Hudson P., Stewart, Jill R., Joseph, Robert, Leviton, Alan, Onderdonk, Andrew B., Kuban, Karl C. K., Heeren, Timothy, O’Shea, T. Michael, Fry, Rebecca C., Shah, Bhahvesh, Singh, Rachana, Van Marter, Linda, Martin, Camilla, Ware, Janice, Cole, Cynthia, Perrin, Ellen, Bednarek, Frank, Frazier, Jean A., Ehrenkranz, Richard, Benjamin, Jennifer, Bose, Carl, Warner, Diane, Engelke, Steve, Poortenga, Mariel, Pastyrnak, Steve, Karna, Padu, Paneth, Nigel, Lenski, Madeleine, Schreiber, Michael, Hunter, Scott, Msall, Michael, Batton, Danny, Klarr, Judith, Christianson, Karen, Klein, Deborah, Pimental, Maureen, Hallisey, Collen, Coster, Taryn, Nylen, Ellen, Neger, Emily, Mattern, Kathryn, Venuti, Lauren, Powers, Beth, Foley, Ann, Williams, Joanne, Romano, Elaine, Hiatt, Debbie, Peters, Nancy |
| المساهمون: | Foundation for the National Institutes of Health |
| المصدر: | Journal of Perinatology ; volume 40, issue 2, page 306-315 ; ISSN 0743-8346 1476-5543 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2019 |
| الوصف: | Objective Infection of the placenta has been associated with preterm birth as well as neurocognitive impairment. This study aimed to determine whether specific bacterial species in the placenta of extremely preterm pregnancies are associated with neurological deficits later in life. Study Design Using data from 807 children in the ELGAN study the risks of a low score on six neurological assessments in relation to 15 different microbes were quantified with odds ratios. Results The presence of certain microbial species in the placenta was associated with lower scores on numerical and oral language assessments. Lactobacillus sp. was associated with decreased risk of a low oral language score and a composite measure of IQ and executive function. Conclusion Placental microorganisms were associated with neurocognitive, but not social-communicative, outcomes at age 10. In contrast, the presence of the anti-inflammatory Lactobacillus sp. in the placenta was associated with a lower risk of impaired neurocognitive functions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41372-019-0505-8 |
| الاتاحة: | http://dx.doi.org/10.1038/s41372-019-0505-8 https://www.nature.com/articles/s41372-019-0505-8.pdf https://www.nature.com/articles/s41372-019-0505-8 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.E9C8B9BF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41372-019-0505-8 |
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