Academic Journal
Comparative assessment of radiation therapy–induced vasculitis using [18F]FDG-PET/CT in patients with non-small cell lung cancer treated with proton versus photon radiotherapy ; ENEngelskEnglishComparative assessment of radiation therapy–induced vasculitis using [18F]FDG-PET/CT in patients with non-small cell lung cancer treated with proton versus photon radiotherapy
| العنوان: | Comparative assessment of radiation therapy–induced vasculitis using [18F]FDG-PET/CT in patients with non-small cell lung cancer treated with proton versus photon radiotherapy ; ENEngelskEnglishComparative assessment of radiation therapy–induced vasculitis using [18F]FDG-PET/CT in patients with non-small cell lung cancer treated with proton versus photon radiotherapy |
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| المؤلفون: | Evanson, D., Griffin, M., O’Reilly, S.E., Johnson, T., Werner, T., Kothekar, E., Jahangiri, P., Simone, C.B., Swisher-McClure, S., Feigenberg, S.J., Rootwelt-Revheim, Mona-Elisabeth, Zou, J., Alavi, A. |
| المصدر: | 1619-7070. |
| سنة النشر: | 2024 |
| المجموعة: | Universitet i Oslo: Digitale utgivelser ved UiO (DUO) |
| الوصف: | Purpose To assess radiation therapy (RT)-induced vasculitis in patients with non-small cell lung cancer (NSCLC) by examining changes in the uptake of 18 F-fluoro-D-deoxyglucose ([ 18 F]FDG) by positron emission tomography/computed tomography (PET/CT) images of the ascending aorta (AA), descending aorta (DA), and aortic arch (AoA) before and after proton and photon RT. Method Thirty-five consecutive locally advanced NSCLC patients were definitively treated with proton ( n = 27) or photon ( n = 8) RT and concurrent chemotherapy. The patients were prospectively enrolled to undergo [ 18 F]FDG-PET/CT imaging before and 3 months after RT. An adaptive contrast-oriented thresholding algorithm was applied to generate mean standardized uptake values (SUVmean) for regions of interest (ROIs) 3 mm outside and 3 mm inside the outer perimeter of the AA, DA, and AoA. These ROIs were employed to exclusively select the aortic wall and remove the influence of blood pool activity. SUVmeans before and after RT were compared using two-tailed paired t -tests. Results RT treatments were associated with increased SUVmeans in the AA, DA, and AoA—1.9%, 0.3%, and 1.3% for proton and 15.8%, 9.5%, and 15.5% for photon, respectively. There was a statistically significant difference in the ∆SUVmean (post-RT SUVmean − pre-RT SUVmean) in patients treated with photon RT when compared to ∆SUVmean in patients treated with proton RT in the AA ( p = 0.043) and AoA ( p = 0.015). There was an average increase in SUVmean that was related to dose for photon patients (across structures), but that was not seen for proton patients, although the increase was not statistically significant. Conclusion Our results suggest that patients treated with photon RT for NSCLC may exhibit significantly more RT-induced inflammation (measured as ∆SUVmean) in the AA and AoA when compared to patients who received proton RT. Knowledge gained from further analyses in larger cohorts could aid in treatment planning and help prevent the significant morbidity and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Evanson, D. Griffin, M. O’Reilly, S.E. Johnson, T. Werner, T. Kothekar, E. Jahangiri, P. Simone, C.B. Swisher-McClure, S. Feigenberg, S.J. Rootwelt-Revheim, Mona-Elisabeth Zou, J. Alavi, A. . Comparative assessment of radiation therapy–induced vasculitis using [18F]FDG-PET/CT in patients with non-small cell lung cancer treated with proton versus photon radiotherapy. European Journal of Nuclear Medicine and Molecular Imaging. 2023; http://hdl.handle.net/10852/108863; 2219348; info:ofi/fmt:kev:mtx:ctx&ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European Journal of Nuclear Medicine and Molecular Imaging&rft.volume=&rft.spage=&rft.date=2023; European Journal of Nuclear Medicine and Molecular Imaging; https://doi.org/10.1007/s00259-023-06535-3 |
| DOI: | 10.1007/s00259-023-06535-3 |
| الاتاحة: | http://hdl.handle.net/10852/108863 https://doi.org/10.1007/s00259-023-06535-3 |
| Rights: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.E9A3B2C0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00259-023-06535-3 |
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