Academic Journal
Gm14230 controls Tbc1d24 cytoophidia and neuronal cellular juvenescence.
| العنوان: | Gm14230 controls Tbc1d24 cytoophidia and neuronal cellular juvenescence. |
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| المؤلفون: | MORIMUNE Takao, TANO Ayami, TANAKA Yuya, YUKIUE Haruka, YAMAMOTO Takefumi, TOOYAMA Ikuo, MARUO Yoshihiro, NISHIMURA Masaki, MORI Masaki, 森宗 孝夫, 田埜 郁実, 田中 雄也, 雪上 晴加, 山元 武文, 遠山 育夫, 丸尾 良浩, 西村 正樹, 森 雅樹 |
| المصدر: | http://www.ncbi.nlm.nih.gov/pmc/articles/pmc8062039/. |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2021 |
| المجموعة: | Shiga University of Medical Science Repository BI WAKO / 滋賀医科大学機関リポジトリ |
| الوصف: | It is not fully understood how enzymes are regulated in the tiny reaction field of a cell. Several enzymatic proteins form cytoophidia, a cellular macrostructure to titrate enzymatic activities. Here, we show that the epileptic encephalopathy-associated protein Tbc1d24 forms cytoophidia in neuronal cells both in vitro and in vivo. The Tbc1d24 cytoophidia are distinct from previously reported cytoophidia consisting of inosine monophosphate dehydrogenase (Impdh) or cytidine-5'-triphosphate synthase (Ctps). Tbc1d24 cytoophidia is induced by loss of cellular juvenescence caused by depletion of Gm14230, a juvenility-associated lncRNA (JALNC) and zeocin treatment. Cytoophidia formation is associated with impaired enzymatic activity of Tbc1d24. Thus, our findings reveal the property of Tbc1d24 to form cytoophidia to maintain neuronal cellular juvenescence. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | |
| اللغة: | English |
| تدمد: | 19326203 |
| Relation: | https://doi.org/10.1371/journal.pone.0248517; https://shiga-med.repo.nii.ac.jp/?action=repository_uri&item_id=3860; http://hdl.handle.net/10422/00012970; PLoS ONE, 16(4), (2021-04-22); https://shiga-med.repo.nii.ac.jp/?action=repository_action_common_download&item_id=3860&item_no=1&attribute_id=17&file_no=1 |
| الاتاحة: | http://hdl.handle.net/10422/00012970 https://shiga-med.repo.nii.ac.jp/?action=repository_uri&item_id=3860 https://shiga-med.repo.nii.ac.jp/?action=repository_action_common_download&item_id=3860&item_no=1&attribute_id=17&file_no=1 |
| Rights: | © 2021 Morimune et al. |
| رقم الانضمام: | edsbas.E99ED674 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
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