Academic Journal
Time-Dependent COVID-19 Mortality in Patients with Cancer: An Updated Analysis of the OnCovid Registry
| العنوان: | Time-Dependent COVID-19 Mortality in Patients with Cancer: An Updated Analysis of the OnCovid Registry |
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| المؤلفون: | Pinato D. J., Patel M., Scotti L., Colomba E., Dolly S., Loizidou A., Chester J., Mukherjee U., Zambelli A., Dalla Pria A., Aguilar-Company J., Bower M., Salazar R., Bertuzzi A., Brunet J., Lambertini M., Tagliamento M., Pous A., Sita-Lumsden A., Srikandarajah K., Colomba J., Pommeret F., Segui E., Generali D., Grisanti S., Pedrazzoli P., Rizzo G., Libertini M., Moss C., Evans J. S., Russell B., Harbeck N., Vincenzi B., Biello F., Bertulli R., Ottaviani D., Linan R., Rossi S., Carmona-Garcia M. C., Tondini C., Fox L., Baggi A., Fotia V., Parisi A., Porzio G., Queirolo P., Cruz C. A., Saoudi-Gonzalez N., Felip E., Roque Lloveras A., Newsom-Davis T., Sharkey R., Roldan E., Reyes R., Zoratto F., Earnshaw I., Ferrante D., Marco-Hernandez J., Ruiz-Camps I., Gaidano G., Patriarca A., Bruna R., Sureda A., Martinez-Vila C., Sanchez De Torre A., Berardi R., Giusti R., Mazzoni F., Guida A., Rimassa L., Chiudinelli L., Franchi M., Krengli M., Santoro A., Prat A., Tabernero J., Van Hemelrijck M., Diamantis N., Gennari A., Cortellini A. |
| المساهمون: | Pinato, D. J., Patel, M., Scotti, L., Colomba, E., Dolly, S., Loizidou, A., Chester, J., Mukherjee, U., Zambelli, A., Dalla Pria, A., Aguilar-Company, J., Bower, M., Salazar, R., Bertuzzi, A., Brunet, J., Lambertini, M., Tagliamento, M., Pous, A., Sita-Lumsden, A., Srikandarajah, K., Colomba, J., Pommeret, F., Segui, E., Generali, D., Grisanti, S., Pedrazzoli, P., Rizzo, G., Libertini, M., Moss, C., Evans, J. S., Russell, B., Harbeck, N., Vincenzi, B., Biello, F., Bertulli, R., Ottaviani, D., Linan, R., Rossi, S., Carmona-Garcia, M. C., Tondini, C., Fox, L., Baggi, A., Fotia, V., Parisi, A., Porzio, G., Queirolo, P., Cruz, C. A., Saoudi-Gonzalez, N., Felip, E., Roque Lloveras, A., Newsom-Davis, T., Sharkey, R., Roldan, E., Reyes, R., Zoratto, F., Earnshaw, I., Ferrante, D., Marco-Hernandez, J., Ruiz-Camps, I., Gaidano, G., Patriarca, A., Bruna, R., Sureda, A., Martinez-Vila, C., Sanchez De Torre, A., Berardi, R., Giusti, R., Mazzoni, F., Guida, A., Rimassa, L., Chiudinelli, L., Franchi, M., Krengli, M., Santoro, A., Prat, A., Tabernero, J., Van Hemelrijck, M., Diamantis, N., Gennari, A., Cortellini, A. |
| بيانات النشر: | American Medical Association 330 N WABASH AVE, STE 39300, CHICAGO, IL 60611-5885 USA |
| سنة النشر: | 2022 |
| المجموعة: | Università degli Studi di Genova: CINECA IRIS |
| مصطلحات موضوعية: | Aged, Female, Human, Infant, Male, Pandemic, Registrie, SARS-CoV-2, COVID-19, Neoplasms |
| الوصف: | Importance: Whether the severity and mortality of COVID-19 in patients with cancer have improved in terms of disease management and capacity is yet to be defined. Objective: To test whether severity and mortality from COVID-19 among patients with cancer have improved during the course of the pandemic. Design, Setting, and Participants: OnCovid is a European registry that collects data on consecutive patients with solid or hematologic cancer and COVID-19. This multicenter case series study included real-world data from 35 institutions across 6 countries (UK, Italy, Spain, France, Belgium, and Germany). This update included patients diagnosed between February 27, 2020, and February, 14, 2021. Inclusion criteria were confirmed diagnosis of SARS-CoV-2 infection and a history of solid or hematologic cancer. Exposures: SARS-CoV-2 infection. Main Outcomes and Measures: Deaths were differentiated at 14 days and 3 months as the 2 landmark end points. Patient characteristics and outcomes were compared by stratifying patients across 5 phases (February to March 2020, April to June 2020, July to September 2020, October to December 2020, and January to February 2021) and across 2 major outbreaks (February to June 2020 and July 2020 to February 2021). Results: At data cutoff, 2795 consecutive patients were included, with 2634 patients eligible for analysis (median [IQR] age, 68 [18-77] years; 52.8% men). Eligible patients demonstrated significant time-dependent improvement in 14-day case-fatality rate (CFR) with estimates of 29.8% (95% CI, 0.26-0.33) for February to March 2020; 20.3% (95% CI, 0.17-0.23) for April to June 2020; 12.5% (95% CI, 0.06-22.90) for July to September 2020; 17.2% (95% CI, 0.15-0.21) for October to December 2020; and 14.5% (95% CI, 0.09-0.21) for January to February 2021 (all P <.001) across the predefined phases. Compared with the second major outbreak, patients diagnosed in the first outbreak were more likely to be 65 years or older (974 of 1626 [60.3%] vs 564 of 1008 [56.1%]; P =.03), have at least ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/34817562; info:eu-repo/semantics/altIdentifier/wos/WOS:000722720800001; volume:8; firstpage:114; lastpage:122; numberofpages:9; journal:JAMA ONCOLOGY; http://hdl.handle.net/11567/1074582; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85120565280 |
| DOI: | 10.1001/jamaoncol.2021.6199 |
| الاتاحة: | http://hdl.handle.net/11567/1074582 https://doi.org/10.1001/jamaoncol.2021.6199 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E9361A09 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1001/jamaoncol.2021.6199 |
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