Academic Journal
An Optimized Terpene Profile for a New Medical Cannabis Oil
| العنوان: | An Optimized Terpene Profile for a New Medical Cannabis Oil |
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| المؤلفون: | Valentina Maggini, Lorenzo Calvi, Tommaso Pelagatti, Eugenia Rosaria Gallo, Celine Civati, Carlo Privitera, Flavio Squillante, Paolo Maniglia, Domenico Di Candia, Roberto Spampatti, Fabio Firenzuoli |
| المساهمون: | V. Maggini, L. Calvi, T. Pelagatti, E. Rosaria Gallo, C. Civati, C. Privitera, F. Squillante, P. Maniglia, D. DI CANDIA, R. Spampatti, F. Firenzuoli |
| بيانات النشر: | MDPI |
| سنة النشر: | 2022 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Cannabis sativa L, medical use, oil preparation, extraction method, cannabinoid, monoterpene, sesquiterpene, oxidized terpene, Settore MED/43 - Medicina Legale |
| الوصف: | The purpose of this analytical study was to develop an advanced formulation of medical Cannabis oil (MCO) comparing the chemical profile of different extracts obtained with two existing methods (SIFAP and CALVI) and one original upgraded (CERFIT) method. Preparation methods were applied with varying solvent, temperature, and duration of the decarboxylation and extraction steps. HPLC-MS/MS TSQ and GC/FID-HS analyses were performed to investigate cannabinoid and terpene contents in the three oil extracts. Cannabinoids profile remained comparable between the formulations. CERFIT extracts exhibited a superior quantity of total terpene hydrocarbon forms (e.g., limonene and α-pinene) with no degradation occurrence (i.e., oxidized terpenes not quantifiable). Thus, this new method optimized the phytochemical profile of the MCO presenting a value opportunity to obtain a standardized high-level therapeutic product. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/35214031; info:eu-repo/semantics/altIdentifier/wos/WOS:000765185000001; volume:14; issue:2; firstpage:1; lastpage:16; numberofpages:16; journal:PHARMACEUTICS; https://hdl.handle.net/2434/908410; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85124473244 |
| DOI: | 10.3390/pharmaceutics14020298 |
| الاتاحة: | https://hdl.handle.net/2434/908410 https://doi.org/10.3390/pharmaceutics14020298 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E91B45C6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/pharmaceutics14020298 |
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