Academic Journal
Cost of non-persistence with oral bisphosphonates in post-menopausal osteoporosis treatment in France.
| العنوان: | Cost of non-persistence with oral bisphosphonates in post-menopausal osteoporosis treatment in France. |
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| المؤلفون: | Cotté, François-Emery, de Pouvourville, Gérard |
| المساهمون: | Health Outcomes Studies, Laboratoire GlaxoSmithKline, CERMES3 - Centre de recherche Médecine, sciences, santé, santé mentale, société (CERMES3 - UMR 8211 / U988 / UM 7), École des hautes études en sciences sociales (EHESS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ESSEC Business School |
| المصدر: | ISSN: 1472-6963 ; BMC Health Services Research ; https://inserm.hal.science/inserm-00663633 ; BMC Health Services Research, 2011, 11 (1), pp.151. ⟨10.1186/1472-6963-11-151⟩. |
| بيانات النشر: | HAL CCSD BioMed Central |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | osteoporosis, bisphosphonate, adherence, persistence, cost, modelling study, MESH: Aged, MESH: Middle Aged, MESH: Monte Carlo Method, MESH: Osteoporosis, Postmenopausal, MESH: Administration, Oral, 80 and over, MESH: Bone Density Conservation Agents, MESH: Costs and Cost Analysis, MESH: Diphosphonates, MESH: Female, MESH: Fractures, Bone, MESH: France, MESH: Humans, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie |
| الوصف: | International audience ; BACKGROUND: During the last decade, oral bisphosphonates (BP) became the most widely prescribed pharmacologic class for post-menopausal osteoporosis. However, many surveys revealed the important issue of poor persistence with those drugs resulting in a failure of treatment to reduce fracture risk sufficiently. Using a published Markov model, this study analyses the economic impact of non-persistence with bisphosphonates in the context of the introduction of generics in France. METHODS: Direct costs of vertebral, hip and wrist fracture were assessed and included in an existing 10-year Markov model developed to analyse consequences of non-persistence. Three alternatives of comparison were set: no treatment, real-world persistence, and ideal persistence. Simulated patients' characteristics matched those from a French observational study and the real-world adherence alternative employed persistence data from published database analysis. The risk of fracture of menopausal women and the risk reduction associated with the drugs were based on results reported in clinical trials. Incremental cost-effectiveness ratios (ICERs) were calculated first between real-world adherence and no treatment alternatives, and second between ideal and real-world persistence alternatives. The cost of non-persistence was defined as the difference between total cost of ideal and real-world persistence alternatives. RESULTS: Within fractured women population, mean costs of 10-year management of fracture were significantly different between the three alternatives with €7,239 (± €4,783), €6,711 (± €4,410) and €6,134 (± €3,945) in the no-treatment, the real-world and ideal persistence alternatives, respectively (p < 0.0001). Cost-effectiveness ratio for real-world treatment persistence compared with no-treatment alternative was found dominant and as well, alternative of ideal persistence dominated the former. Each ten percentage point of persistence gain amounted to €58 per patient, and extrapolation resulted in a ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/21702989; inserm-00663633; https://inserm.hal.science/inserm-00663633; https://inserm.hal.science/inserm-00663633/document; https://inserm.hal.science/inserm-00663633/file/1472-6963-11-151.pdf; PUBMED: 21702989 |
| DOI: | 10.1186/1472-6963-11-151 |
| الاتاحة: | https://inserm.hal.science/inserm-00663633 https://inserm.hal.science/inserm-00663633/document https://inserm.hal.science/inserm-00663633/file/1472-6963-11-151.pdf https://doi.org/10.1186/1472-6963-11-151 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.E8CA6EA9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/1472-6963-11-151 |
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