Academic Journal
Recombinant Inbred Mice as Models for Experimental Precision Medicine and Biology
| العنوان: | Recombinant Inbred Mice as Models for Experimental Precision Medicine and Biology |
|---|---|
| المؤلفون: | Ashbrook, David G. |
| المساهمون: | Lu, Lu |
| المصدر: | MODID-6d55e02e354:IntechOpen |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Medical, bisacsh:MED000000 |
| الوصف: | Recombinant inbred rodents form immortal genome-types that can be resampled deeply at many stages, in both sexes, and under multiple experimental conditions to model genome-environment interactions and to test genome-phenome predictions. This allows for experimental precision medicine, for which sophisticated causal models of complex interactions among DNA variants, phenotype variants at many levels, and innumerable environmental factors are required. Large families and populations of isogenic lines of mice and rats are now available and have been used across fields of biology. We will use the BXD recombinant inbred family and their derived diallel cross population as an example for predictive, experimental precision medicine and biology. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://openresearchlibrary.org/viewer/66f4fb95-24c4-452b-98a7-64abccf79ff2; https://openresearchlibrary.org/ext/api/media/66f4fb95-24c4-452b-98a7-64abccf79ff2/assets/external_content.pdf |
| الاتاحة: | https://openresearchlibrary.org/viewer/66f4fb95-24c4-452b-98a7-64abccf79ff2 https://openresearchlibrary.org/ext/api/media/66f4fb95-24c4-452b-98a7-64abccf79ff2/assets/external_content.pdf |
| Rights: | https://creativecommons.org/licenses/by/4.0/legalcode |
| رقم الانضمام: | edsbas.E8C89AEE |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |