Academic Journal
Lung Transplant With Cardiopulmonary Bypass:Impact of Blood Transfusion on Rejection, Function, and Late Mortality.
| العنوان: | Lung Transplant With Cardiopulmonary Bypass:Impact of Blood Transfusion on Rejection, Function, and Late Mortality. |
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| المؤلفون: | Ong, LP, Sachdeva, A, Ramesh, BC, Muse, H, Wallace, K, Parry, G, Clark, SC |
| المصدر: | Ong , LP , Sachdeva , A , Ramesh , BC , Muse , H , Wallace , K , Parry , G & Clark , SC 2016 , ' Lung Transplant With Cardiopulmonary Bypass : Impact of Blood Transfusion on Rejection, Function, and Late Mortality. ' , Annals of Thoracic Surgery , pp. 512-519 . https://doi.org/10.1016/j.athoracsur.2015.07.048 |
| سنة النشر: | 2016 |
| المجموعة: | The University of Manchester: Research Explorer - Publications |
| مصطلحات موضوعية: | ResearchInstitutes_Networks_Beacons/mcrc, Manchester Cancer Research Centre |
| الوصف: | Background Allogeneic blood transfusion has been associated with immune modulation in other solid organ transplants. Within cardiothoracic surgery, allogeneic blood transfusion is associated with greater postoperative morbidity and mortality. We investigated the impact of allogeneic blood transfusion on rejection, function, and late mortality within lung transplantation. Methods A retrospective review was made of 311 adult patients who underwent bilateral lung transplantation with cardiopulmonary bypass from 2003 to 2013. Patients were stratified based on the amount of blood products transfused within 24 hours of transplantation. Kaplan-Meier methods and multivariate Cox proportional hazards models were used for time to first rejection/death and all-cause mortality analyses. Results In all, 174 men and 137 women (mean age 41.4 ± 14.0 years) utilized a median number of 3 units (range, 0 to 40) of red blood cells (RBC), 2 units (range, 0 to 26) of fresh frozen plasma (FFP), and 1 unit (range, 0 to 7) of platelets within the first 24 hours of transplantation. Time to first treated rejection/death was not statistically different whether patients were transfused with more or less than the median number of units of RBC (unadjusted p = 0.233, adjusted hazard ratio [HR] 1.02, 95% confidence interval [CI]: 0.75 to 1.40, p = 0.177), FFP (unadjusted p = 0.146, adjusted HR 1.29, 95% CI: 0.95 to 1.76, p = 0.108), or platelets (unadjusted p = 0.701, adjusted HR 0.74, 95% CI: 0.47 to 1.15, p = 0.177). Rate of rejection and number of rejection episodes per patient at 1 year after transplant were not statistically different. Forced expiratory volume in 1 second expressed as percentage of forced vital capacity at 3 and 6 months was similar for all groups. Unadjusted early all-cause mortality was not influenced by RBC (p = 0.162) or FFP (p = 0.298) but was significantly different with more platelets (p = 0.032). Adjusted 10-year mortality showed no significant differences for RBC (HR 1.12, 95% CI: 0.70 to 1.79, p = 0.645), FFP (HR ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/j.athoracsur.2015.07.048 |
| الاتاحة: | https://research.manchester.ac.uk/en/publications/65ee9e80-9744-46d8-87f3-96fe72e554bc https://doi.org/10.1016/j.athoracsur.2015.07.048 http://europepmc.org/abstract/med/26453422 |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.E8B40375 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.athoracsur.2015.07.048 |
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