Academic Journal
Enantioselective Partitioning of Racemic Ibuprofen in a Biphasic Recognition Chiral Extraction System
| العنوان: | Enantioselective Partitioning of Racemic Ibuprofen in a Biphasic Recognition Chiral Extraction System |
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| المؤلفون: | Tang, Kewen, Song, Litao, Pan, Yang, Jiang, Xinyu, Miao, Jiabing |
| المصدر: | Chinese Journal of Chemistry ; volume 28, issue 1, page 119-124 ; ISSN 1001-604X 1614-7065 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2010 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Enantioselective partitioning of ibuprofen enantiomers in a biphasic recognition chiral extraction system was studied. A combination of hydrophobic L ‐isobutyl tartrate in organic phase and hydrophilic β ‐cyclodextrin derivative in aqueous phase is necessary to establish a biphasic recognition chiral extraction system. The studies performed involve an enantioselective extraction in a biphasic system, where ibuprofen enantiomers form four complexes with the β ‐cyclodextrin derivative in aqueous phase and the D ( L )‐isobutyl tartrate in organic phase, respectively. In these biphasic resolutions, the types and the concentrations of the extractants, pH and temperature all exert a considerable influence on the biphasic recognition process. Good enantioselectivities for ibuprofen enantiomers were obtained at pH≦2.5 and a ratio of 2:1 of [ L ‐isobutyl tartrate] to [HP‐ β ‐CD]. Biphasic recognition chiral extraction is of strong chiral separation ability, and may be very helpful to optimize the extraction systems and realize the large‐scale production of enantiomers. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/cjoc.201090026 |
| الاتاحة: | http://dx.doi.org/10.1002/cjoc.201090026 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fcjoc.201090026 https://onlinelibrary.wiley.com/doi/pdf/10.1002/cjoc.201090026 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.E88B98E3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/cjoc.201090026 |
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