Academic Journal
Comparison of Enlarged Perivascular Spaces in Early-Onset and Late-Onset Alzheimer Disease-related Cognitive Impairment ; A Single Clinic-based Study in South Korea
| العنوان: | Comparison of Enlarged Perivascular Spaces in Early-Onset and Late-Onset Alzheimer Disease-related Cognitive Impairment ; A Single Clinic-based Study in South Korea |
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| المؤلفون: | Jung, Na-Yeon, Je, Yuri, Ham, Hong-Gi, Park, Yu Hyun, Kim, Tae-Yun, Go, Min-su, Lee, Hye-In, Kim, Da Eun, Lee, Myung Jun, Seo, Sang Won, Kim, Eun-Joo |
| المصدر: | Alzheimer Disease & Associated Disorders ; ISSN 0893-0341 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: | 2024 |
| الوصف: | We examined whether there were differences in the presence of centrum semiovale-enlarged perivascular spaces (CSO-ePVS) and basal ganglia-ePVS (BG-ePVS) among patients with Alzheimer disease-related cognitive impairment (ADCI) based on their age of onset. Out of a total of 239 patients with cognitive impairment, 155 with positive amyloid-PET results were included. Among these, 43 had early-onset ADCI (EOADCI) and 112 had late-onset ADCI (LOADCI). Patients with LOADCI exhibited a higher prevalence of hypertension, lacunes, white matter hyperintensities, and BG-ePVS than those with EOADCI. BG-ePVS showed a significant correlation with age at the onset and the number of lacunes, whereas CSO-ePVS did not exhibit any association. The higher prevalence of BG-ePVS in patients with LOADCI might be attributable to vascular risk factors (hypertension) and cerebral small vessel disease (CSVD). These findings support the hypothesis that BG-ePVS is associated with CSVD and vascular risk factors, whereas CSO-ePVS is associated with cerebral amyloid angiopathy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1097/wad.0000000000000614 |
| DOI: | 10.1097/WAD.0000000000000614 |
| الاتاحة: | http://dx.doi.org/10.1097/wad.0000000000000614 https://journals.lww.com/10.1097/WAD.0000000000000614 |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.E86AA1B4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/wad.0000000000000614 |
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