Academic Journal
Endoscopically removed rectal NETs: a nationwide cohort study
| العنوان: | Endoscopically removed rectal NETs: a nationwide cohort study |
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| المؤلفون: | Kuiper, T, van Oijen, MG, van Velthuysen, MLF (M. Loes), van Lelyveld, N, Leerdam, ME, Vleggaar, FD, Klümpen, HJ |
| المصدر: | Kuiper , T , van Oijen , MG , van Velthuysen , MLF , van Lelyveld , N , Leerdam , ME , Vleggaar , FD & Klümpen , HJ 2021 , ' Endoscopically removed rectal NETs: a nationwide cohort study ' , International Journal of Colorectal Disease , vol. 36 , no. 3 , pp. 535-541 . https://doi.org/10.1007/s00384-020-03801-w |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | /dk/atira/pure/keywords/researchprograms/AFL001000/EMCOR01, name=EMC OR-01 |
| الوصف: | Purpose: Rectal neuroendocrine tumours (NETs) often present as an incidental finding during colonoscopy. Complete endoscopic resection of low-grade NETs up to 10 mm is considered safe. Whether this is also safe for NETs up to 20 mm is unclear. We performed a nationwide study to determine the risk of lymph node and distant metastases in endoscopically removed NETs. Methods: All endoscopically removed rectal NETs between 1990 and 2010 were identified using the national pathology database (PALGA). Each NET was stratified according to size, grade and resection margin. Follow-up was until February 2016. Results: Between 1990 and 2010, a total of 310 NETs smaller than 20 mm were endoscopically removed. Mean size of NETs was 7.4 mm (SD 3.5). In 49% of NETs (n = 153), no grade (G) could be assessed from the pathology report, 1% was G2 (n = 3), and the remaining NETs were G1. Median follow up was 11.6 years (range 4.9–26.0). During follow-up, 30 patients underwent surgical resection. Lymph node or distant metastasis was seen in 3 patients (1%) which all had a grade 2 NET. Mean time from endoscopic resection to diagnosis of metastases was 6.1 years (95% CI 2.9–9.2). Conclusion: No lymph node or distant metastases were seen in endoscopically removed G1 NETs up to 20 mm during the long follow-up of this nationwide study. This adds evidence to the ENET guideline that endoscopic resection of G1 NETs up to 20 mm appears to be safe. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1007/s00384-020-03801-w |
| الاتاحة: | https://pure.eur.nl/en/publications/9d096c90-baaf-4be7-a560-6e506f5f6100 https://doi.org/10.1007/s00384-020-03801-w http://www.scopus.com/inward/record.url?scp=85096441948&partnerID=8YFLogxK https://scholarlypublications.universiteitleiden.nl/access/item%3A3182261/view |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E829D227 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00384-020-03801-w |
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