Academic Journal
Treatment and overall survival of four types of non-metastatic periampullary cancer:nationwide population-based cohort study
| العنوان: | Treatment and overall survival of four types of non-metastatic periampullary cancer:nationwide population-based cohort study |
|---|---|
| المؤلفون: | de Jong, Evelien J M, van der Geest, Lydia G, Besselink, Marc G, Bouwense, Stefan A W, Buijsen, Jeroen, Dejong, C H C, Koerkamp, Bas G, Heij, Lara R, de Hingh, Ignace H J T, Hoge, Chantal, Kazemier, Geert, van Laarhoven, Hanneke W M, de Meijer, Vincent E, Stommel, Martijn W J, Tjan-Heijnen, Vivianne C G, Valkenburg-van Iersel, Liselot B J, Wilmink, Johanna W, Geurts, Sandra M E, de Vos-Geelen, Judith |
| المصدر: | Dutch Pancreatic Cancer Group , de Jong , E J M , van der Geest , L G , Besselink , M G , Bouwense , S A W , Buijsen , J , Dejong , C H C , Koerkamp , B G , Heij , L R , de Hingh , I H J T , Hoge , C , Kazemier , G , van Laarhoven , H W M , de Meijer , V E , Stommel , M W J , Tjan-Heijnen , V C G , Valkenburg-van Iersel , L B J , Wilmink .... |
| سنة النشر: | 2022 |
| المجموعة: | University of Groningen research database |
| الوصف: | BACKGROUND: Periampullary adenocarcinoma consists of pancreatic adenocarcinoma (PDAC), distal cholangiocarcinoma (DC), ampullary cancer (AC), and duodenal adenocarcinoma (DA). The aim of this study was to assess treatment modalities and overall survival by tumor origin. METHODS: Patients diagnosed with non-metastatic periampullary cancer in 2012-2018 were identified from the Netherlands Cancer Registry. OS was studied with Kaplan-Meier analysis and multivariable Cox regression analyses, stratified by origin. RESULTS: Among the 8758 patients included, 68% had PDAC, 13% DC, 12% AC, and 7% DA. Resection was performed in 35% of PDAC, 56% of DC, 70% of AC, and 59% of DA. Neoadjuvant and/or adjuvant therapy was administered in 22% of PDAC, 7% of DC, 7% of AC, and 12% of DA. Three-year OS was highest for AC (37%) and DA (34%), followed by DC (21%) and PDAC (11%). Adjuvant therapy was associated with improved OS among PDAC (HR = 0.62; 95% CI 0.55-0.69) and DC (HR = 0.69; 95% CI 0.48-0.98), but not AC (HR = 0.87; 95% CI 0.62-1.22) and DA (HR = 0.85; 95% CI 0.48-1.50). CONCLUSION: This retrospective study identified considerable differences in treatment modalities and OS between the four periampullary cancer origins in daily clinical practice. An improved OS after adjuvant chemotherapy could not be demonstrated in patients with AC and DA. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1016/j.hpb.2022.01.009 |
| الاتاحة: | https://hdl.handle.net/11370/f699f96e-e062-4664-94c7-9f61406f7838 https://research.rug.nl/en/publications/f699f96e-e062-4664-94c7-9f61406f7838 https://doi.org/10.1016/j.hpb.2022.01.009 https://pure.rug.nl/ws/files/245838953/1_s2.0_S1365182X22000442_main.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E8005CAA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.hpb.2022.01.009 |
|---|