Academic Journal
Renal Cell Carcinoma in End-Stage Kidney Disease and the Role of Transplantation
| العنوان: | Renal Cell Carcinoma in End-Stage Kidney Disease and the Role of Transplantation |
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| المؤلفون: | Samuel Robinson, Alena Nag, Benjamin Peticca, Tomas Prudencio, Antonio Di Carlo, Sunil Karhadkar |
| المصدر: | Cancers, Vol 16, Iss 1, p 3 (2023) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | renal cell carcinoma, end-stage renal disease, transplantation, immunosuppression, renal malignancy, kidney transplant, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Kidney transplant patients have a higher risk of renal cell carcinoma (RCC) compared to non-transplanted end-stage kidney disease (ESKD) patients. This increased risk has largely been associated with the use of immunosuppression; however, recent genetic research highlights the significance of tissue specificity in cancer driver genes. The implication of tissue specificity becomes more obscure when addressing transplant patients, as two distinct metabolic environments are present within one individual. The oncogenic potential of donor renal tissue is largely unknown but assumed to pose minimal risk to the kidney transplant recipient (KTR). Our review challenges this notion by examining how donor and recipient microenvironments impact a transplant recipient’s associated risk of renal cell carcinoma. In doing so, we attempt to encapsulate how ESKD-RCC and KTR-RCC differ in their incidence, pathogenesis, outcome, and approach to management. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2072-6694 |
| Relation: | https://www.mdpi.com/2072-6694/16/1/3; https://doaj.org/toc/2072-6694; https://doaj.org/article/afdb3828054a44d981c60f708c7c3713 |
| DOI: | 10.3390/cancers16010003 |
| الاتاحة: | https://doi.org/10.3390/cancers16010003 https://doaj.org/article/afdb3828054a44d981c60f708c7c3713 |
| رقم الانضمام: | edsbas.E7F6BB7B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726694 |
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| DOI: | 10.3390/cancers16010003 |