Academic Journal
Comparison of remifentanil versus regional anaesthesia in children anaesthetised with isoflurane/nitrous oxide
| العنوان: | Comparison of remifentanil versus regional anaesthesia in children anaesthetised with isoflurane/nitrous oxide |
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| المؤلفون: | Prys‐Roberts, C., Lerman, J., Murat, I., Taivainen, T., Lopez, T., Lejus, C., Spahr‐Schopfer, I., Splinter, W., Kirkham, A. J. T. |
| المصدر: | Anaesthesia ; volume 55, issue 9, page 870-876 ; ISSN 0003-2409 1365-2044 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2000 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | We compared the efficacy and safety of a remifentanil (0.25 µg.kg −1 .min −1 )‐based balanced anaesthetic technique with a bupivacaine‐based regional anaesthetic technique in an open label, multicentre study in 271 ASA physical status 1 or 2 children aged 1–12 years. Subjects requiring major intra‐abdominal, urological or orthopaedic surgery were randomly allocated to receive either intravenous remifentanil (group R; n = 185) or epidural bupivacaine (group B; n = 86) with isoflurane/nitrous oxide for their anaesthesia. The majority of children in both groups (85% in group R, 78% in group B) showed no defined response to skin incision, and although the mean increase in systolic blood pressure (+11 mmHg) was significantly greater in group R than in group B, this change did not represent a serious haemodynamic disturbance. More children in group R (31%) required interventions to treat hypotension and/or bradycardia than those in group B (12%), but these were easily managed by administration of fluids or anticholinergic drugs. Adverse events, mainly nausea and/or vomiting, occurred in 45% of group R and 42% of group B (NS). The adverse event profile of remifentanil in this study was typical of a potent µ‐opioid receptor agonist. Remifentanil was as effective as epidural or caudal block in providing analgesia and suppressing physiological responses to surgical stimuli in children aged between 1 and 12 years undergoing major abdominal, urological, or orthopaedic surgery under isoflurane/nitrous oxide anaesthesia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1046/j.1365-2044.2000.01607.x |
| DOI: | 10.1046/j.1365-2044.2000.01607.x/fullpdf |
| الاتاحة: | http://dx.doi.org/10.1046/j.1365-2044.2000.01607.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2044.2000.01607.x http://onlinelibrary.wiley.com/wol1/doi/10.1046/j.1365-2044.2000.01607.x/fullpdf |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.E7E24F95 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1046/j.1365-2044.2000.01607.x |
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