Academic Journal
Polymorphisms in genes of the BAFF/ APRIL system may constitute risk factors of B‐ CLL – a preliminary study on a Polish population
| العنوان: | Polymorphisms in genes of the BAFF/ APRIL system may constitute risk factors of B‐ CLL – a preliminary study on a Polish population |
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| المؤلفون: | Jasek, M., Wagner, M., Sobczynski, M., Wolowiec, D., Kuliczkowski, K., Woszczyk, D., Kielbinski, M., Kusnierczyk, P., Frydecka, I., Karabon, L. |
| المساهمون: | National Science Centre Poland |
| المصدر: | Tissue Antigens ; volume 86, issue 4, page 279-284 ; ISSN 0001-2815 1399-0039 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2015 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | The association of single‐nucleotide polymorphisms ( SNPs ) of B‐cell activating factor ( BAFF )/a proliferation‐inducing ligand ( APRIL ) system with B‐cell chronic lymphocytic leukemia (B‐ CLL ) have been suggested, therefore, we investigated 20 SNPs of BAFF , APRIL , BAFF ‐R , transmembrane activator and calcium modulator and cyclophilin‐ligand interactor ( TACI ), B‐cell maturation antigen ( BCMA ) genes and the risk and outcome of B‐ CLL in 187 patients and 296 healthy subjects as well as ligand‐receptor gene × gene interactions. Although the obtained P ‐values for all 20 SNPs did not reach statistical significance for this study (α = 0.003), the high value of the global chi‐squared statistic (χ 2 df = 38 = 52.65; P = 0.0586), and obtained values of odds ratio indicate that rs9514828 ( BAFF ), rs3803800 ( APRIL ) and rs4985726 ( TACI ) may be associated with the risk of B‐ CLL . We observed that the B‐ CLL patients with the genotype rs9514828CT / rs11570136AA were diagnosed with the disease 12 years later than the whole group of patients in this study. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/tan.12641 |
| الاتاحة: | http://dx.doi.org/10.1111/tan.12641 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Ftan.12641 https://onlinelibrary.wiley.com/doi/pdf/10.1111/tan.12641 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.E7C6F49F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/tan.12641 |
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