التفاصيل البيبلوغرافية
| العنوان: |
Conserved Molecular Players Involved in Human Nose Morphogenesis Underlie Evolution of the Exaggerated Snout Phenotype in Cichlids |
| المؤلفون: |
Duenser, Anna, Singh, Pooja, Lecaudey, Laurene Alicia, Sturmbauer, Christian, Albertson, R. Craig, Gessl, Wolfgang, Ahi, Ehsan Pashay |
| المساهمون: |
Organismal and Evolutionary Biology Research Programme |
| بيانات النشر: |
Oxford University Press |
| سنة النشر: |
2023 |
| المجموعة: |
Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: |
Lake Malawi, Lake Tanganyika, RNA-seq, Cichlids, Functional conservation, Snout flap, Biochemistry, cell and molecular biology |
| الوصف: |
Instances of repeated evolution of novel phenotypes can shed light on the conserved molecular mechanisms underlying morphological diversity. A rare example of an exaggerated soft tissue phenotype is the formation of a snout flap in fishes. This tissue flap develops from the upper lip and has evolved in one cichlid genus from Lake Malawi and one genus from Lake Tanganyika. To investigate the molecular basis of snout flap convergence, we used mRNA sequencing to compare two species with snout flap to their close relatives without snout flaps from each lake. Our analysis identified 201 genes that were repeatedly differentially expressed between species with and without snout flap in both lakes, suggesting shared pathways, even though the flaps serve different functions. Shared expressed genes are involved in proline and hydroxyproline metabolism, which have been linked to human skin and facial deformities. Additionally, we found enrichment for transcription factor binding sites at upstream regulatory sequences of differentially expressed genes. Among the enriched transcription factors were members of the FOX transcription factor family, especially foxf1 and foxa2, which showed an increased expression in the flapped snout. Both of these factors are linked to nose morphogenesis in mammals. We also found ap4 (tfap4), a transcription factor showing reduced expression in the flapped snout with an unknown role in craniofacial soft tissue development. As genes involved in cichlid snout flap development are associated with human midline facial dysmorphologies, our findings hint at the conservation of genes involved in midline patterning across distant evolutionary lineages of vertebrates, although further functional studies are required to confirm this. ; Peer reviewed |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Duenser , A , Singh , P , Lecaudey , L A , Sturmbauer , C , Albertson , R C , Gessl , W & Ahi , E P 2023 , ' Conserved Molecular Players Involved in Human Nose Morphogenesis Underlie Evolution of the Exaggerated Snout Phenotype in Cichlids ' , Genome Biology and Evolution , vol. 15 , no. 4 . https://doi.org/10.1093/gbe/evad045; http://hdl.handle.net/10138/358359; 85151890608; 000964169900001 |
| الاتاحة: |
http://hdl.handle.net/10138/358359 |
| Rights: |
unspecified ; cc_by ; info:eu-repo/semantics/openAccess ; openAccess |
| رقم الانضمام: |
edsbas.E7C58A24 |
| قاعدة البيانات: |
BASE |