Academic Journal
Cytotoxic activities of methanol extract and compounds of Porodaedalea pini against colorectal cancer
| العنوان: | Cytotoxic activities of methanol extract and compounds of Porodaedalea pini against colorectal cancer |
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| المؤلفون: | Deveci, Ebru, Tel Çayan, Gülsen, Karakurt, Serdar, Duru, Mehmet Emin |
| المساهمون: | MÜ, Muğla Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümü, orcid:0000-0002-1916-7391, orcid:0000-0001-7252-4880, Tel Çayan, Gülsen, Duru, Mehmet Emin |
| بيانات النشر: | Pamukkale University |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Porodaedalea pini, Colorectal cancer, Cytotoxic activity, Extract, Isolation |
| الوصف: | Porodaedalea pini is a medicinally important mushroom with antioxidant, cytotoxic, immunostimulating, antitumor, antiviral and immunomodulating activities. Therefore, in this study, P. pini methanol extract and isolated compounds from the methanol extract were tested for cytotoxic activities against DLD-1 (colorectal cancer) and CCD-18Co (human colon fibroblast cell line) by using Alamar Blue assay. Cytotoxic activity on DLD-1 was decreased in the order of P. pini methanol extract> 4-(3,4-dihydroxyphenyl)but-3-en-2-one (3)> pinoresinol (2)> ergosta-7,24(28)-dien-3β-ol (1). P. pini methanol extract was determined to have the best cytotoxic activity with the lowest IC50 value on DLD-1 (IC50: 25.33±0.29 µg/mL) and the highest IC50 value on CCD-18Co (434.30±1.45 µg/mL). Within the scope of the findings, it is thought that P. pini mushroom can be used as a new and natural agent in the treatment of colorectal cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 21486905 |
| Relation: | International Journal of Secondary Metabolite; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Deveci̇ E, Tel-Çayan G, Karakurt S, Duru ME (2021) Cytotoxic Activities of Methanol Extract and Compounds of Porodaedalea pini Against Colorectal Cancer. International Journal of Secondary Metabolite 40–48. doi:10.21448/ijsm.793715; https://doi.org/10.21448/ ijsm.793715; https://hdl.handle.net/20.500.12809/9241; 40; 48 |
| DOI: | 10.21448/ |
| الاتاحة: | https://hdl.handle.net/20.500.12809/9241 https://doi.org/10.21448/ ijsm.793715 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E7AF79C1 |
| قاعدة البيانات: | BASE |
| تدمد: | 21486905 |
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| DOI: | 10.21448/ |