Academic Journal
High-risk human papillomavirus distribution according to human immunodeficiency virus status among women with cervical cancer in Abidjan, Côte d'Ivoire, 2018 to 2020
| العنوان: | High-risk human papillomavirus distribution according to human immunodeficiency virus status among women with cervical cancer in Abidjan, Côte d'Ivoire, 2018 to 2020 |
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| المؤلفون: | Boni, Simon P., Tenet, Vanessa, Horo, Apollinaire, Heideman, Daniëlle A. M., Bleeker, Maaike C. G., Tanon, Aristophane, Mian, Boston, Mohenou, Isidore D., Ekouevi, Didier K., Gheit, Tarik, Didi-Kouko Coulibaly, Judith, Tchounga, Boris K., Adoubi, Innocent, Clifford, Gary M., Jaquet, Antoine |
| المصدر: | Boni , S P , Tenet , V , Horo , A , Heideman , D A M , Bleeker , M C G , Tanon , A , Mian , B , Mohenou , I D , Ekouevi , D K , Gheit , T , Didi-Kouko Coulibaly , J , Tchounga , B K , Adoubi , I , Clifford , G M & Jaquet , A 2024 , ' High-risk human papillomavirus distribution according to human immunodeficiency virus status among women with cervical cancer in Abidjan, Côte d'Ivoire, 2018 to 2020 ' , International Journal of .... |
| سنة النشر: | 2024 |
| الوصف: | As human papillomavirus (HPV) immunisation and HPV-based cervical cancer (CC) screening programmes expand across sub-Saharan Africa, we investigated the potential impact of human immunodeficiency virus (HIV) status on high-risk (HR)-HPV distribution among women with CC in Côte d'Ivoire. From July 2018 to June 2020, paraffin-embedded CC specimens diagnosed in Abidjan, Côte d'Ivoire were systematically collected and tested for HR-HPV DNA. Type-specific HR-HPV prevalence was compared according to HIV status. Of the 170 CC specimens analysed (median age 52 years, interquartile range: [43.0-60.0]), 43 (25.3%) were from women living with HIV (WLHIV) with a median CD4 count of 526 [373-833] cells/mm3 and 86% were on antiretroviral therapy (ART). The overall HR-HPV prevalence was 89.4% [95% CI: 84.7-94.1]. All were single HR-HPV infections with no differences according to HIV status (P =.8). Among HR-HPV-positive CC specimens, the most prevalent HR-HPV types were HPV16 (57.2%), HPV18 (19.7%), HPV45 (8.6%) and HPV35 (4.6%), with no significant differences according to HIV status. Altogether, infection with HPV16/18 accounted for 71.1% [95% CI: 55.9-86.2] of CC cases in WLHIV vs 78.9% [95% CI: 71.3-86.5] in women without HIV (P =.3). The study confirms the major role of HPV16/18 in CC in Côte d'Ivoire and should support a regional scale-up of HPV16/18 vaccination programmes regardless of HIV status. However, vaccines targeting additional HR-HPV types, including HPV45 and HPV35, could further decrease future CC incidence in Côte d'Ivoire, both for WLHIV and women without HIV. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/ijc.34774 |
| الاتاحة: | https://research.vumc.nl/en/publications/a664592d-1b1e-4d5e-b42e-bd4ba5137bb0 https://doi.org/10.1002/ijc.34774 http://www.scopus.com/inward/record.url?scp=85176279302&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E7A20AF4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ijc.34774 |
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