Academic Journal
Whole-cell vaccine candidates induce a protective response against virulent Acinetobacter baumannii
| العنوان: | Whole-cell vaccine candidates induce a protective response against virulent Acinetobacter baumannii |
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| المؤلفون: | Dollery, Stephen J., Zurawski, Daniel V., Bushnell, Ruth V., Tobin, John K., Wiggins, Taralyn J., MacLeod, David A., Tasker, Naomi J. P. E. R., Alamneh, Yonas A., Abu-Taleb, Rania, Czintos, Christine M., Su, Wanwen, Escatte, Mariel G., Meeks, Heather N., Daly, Michael J., Tobin, Gregory J. |
| المساهمون: | Defense Threat Reduction Agency |
| المصدر: | Frontiers in Immunology ; volume 13 ; ISSN 1664-3224 |
| بيانات النشر: | Frontiers Media SA |
| سنة النشر: | 2022 |
| المجموعة: | Frontiers (Publisher - via CrossRef) |
| الوصف: | Acinetobacter baumannii causes multi-system diseases in both nosocomial settings and a pre-disposed general population. The bacterium is not only desiccation-resistant but also notoriously resistant to multiple antibiotics and drugs of last resort including carbapenem, colistin, and sulbactam. The World Health Organization has categorized carbapenem-resistant A. baumannii at the top of its critical pathogen list in a bid to direct urgent countermeasure development. Several early-stage vaccines have shown a range of efficacies in healthy mice, but no vaccine candidates have advanced into clinical trials. Herein, we report our findings that both an ionizing γ-radiation-inactivated and a non-ionizing ultraviolet C-inactivated whole-cell vaccine candidate protects neutropenic mice from pulmonary challenge with virulent AB5075, a particularly pathogenic isolate. In addition, we demonstrate that a humoral response is sufficient for this protection via the passive immunization of neutropenic mice. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| DOI: | 10.3389/fimmu.2022.941010 |
| DOI: | 10.3389/fimmu.2022.941010/full |
| الاتاحة: | http://dx.doi.org/10.3389/fimmu.2022.941010 https://www.frontiersin.org/articles/10.3389/fimmu.2022.941010/full |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.E760636C |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fimmu.2022.941010 |
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