Academic Journal
Independent representations of self-motion and object location in barrel cortex output
| العنوان: | Independent representations of self-motion and object location in barrel cortex output |
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| المؤلفون: | Cheung, Jonathan Andrew, Maire, Phillip, Kim, Jinho, Lee, Kiana, Flynn, Garrett, Hires, Samuel Andrew |
| المساهمون: | Petersen, Carl C.H., National Institute of Neurological Disorders and Stroke, Whitehall Foundation |
| المصدر: | PLOS Biology ; volume 18, issue 11, page e3000882 ; ISSN 1545-7885 |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2020 |
| المجموعة: | PLOS Publications (via CrossRef) |
| الوصف: | During active tactile exploration, the dynamic patterns of touch are transduced to electrical signals and transformed by the brain into a mental representation of the object under investigation. This transformation from sensation to perception is thought to be a major function of the mammalian cortex. In primary somatosensory cortex (S1) of mice, layer 5 (L5) pyramidal neurons are major outputs to downstream areas that influence perception, decision-making, and motor control. We investigated self-motion and touch representations in L5 of S1 with juxtacellular loose-seal patch recordings of optogenetically identified excitatory neurons. We found that during rhythmic whisker movement, 54 of 115 active neurons (47%) represented self-motion. This population was significantly more modulated by whisker angle than by phase. Upon active touch, a distinct pattern of activity was evoked across L5, which represented the whisker angle at the time of touch. Object location was decodable with submillimeter precision from the touch-evoked spike counts of a randomly sampled handful of these neurons. These representations of whisker angle during self-motion and touch were independent, both in the selection of which neurons were active and in the angle-tuning preference of coactive neurons. Thus, the output of S1 transiently shifts from a representation of self-motion to an independent representation of explored object location during active touch. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1371/journal.pbio.3000882 |
| الاتاحة: | http://dx.doi.org/10.1371/journal.pbio.3000882 https://dx.plos.org/10.1371/journal.pbio.3000882 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.E7526BC5 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pbio.3000882 |
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