Academic Journal
Impaired SARS-CoV-2-Specific CD8+ T Cells After Infection or Vaccination but Robust Hybrid T Cell Immunity in Patients with Multiple Myeloma ...
| العنوان: | Impaired SARS-CoV-2-Specific CD8+ T Cells After Infection or Vaccination but Robust Hybrid T Cell Immunity in Patients with Multiple Myeloma ... |
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| المؤلفون: | Shoumariyeh, Khalid, Csernalabics, Benedikt, Salimi Alizei, Elahe, Reinscheid, Matthias, Giese, Sebastian, Ciminski, Kevin, Kochs, Georg, Schwemmle, Martin, Lang-Meli, Julia, Maas, Michelle, Roehlen, Natascha, Karl, Vivien, Graeser, Anne, Sogukpinar, Oezlem, Von Metzler, Ivana, Grathwohl, Denise, Rasche, Leo, Hebart, Holger, Kull, Miriam, Emmerich, Florian, Waller, Cornelius Florian, Duyster, Justus, Engelhardt, Monika, Hartmann, Tanja Nicole, Bengsch, Bertram, Boettler, Tobias, Neumann-Haefelin, Christoph, Hofmann, Maike, Thimme, Robert, Luxenburger, Hendrik |
| بيانات النشر: | Universität Ulm |
| سنة النشر: | 2024 |
| المجموعة: | DataCite Metadata Store (German National Library of Science and Technology) |
| مصطلحات موضوعية: | Multiple myeloma, Immunosuppression, COVID-19, SARS-CoV-2, mRNA vaccination, Infection, T cells, Adaptive immune response, DDC 610 / Medicine & health |
| الوصف: | Background: Multiple myeloma (MM) patients are at high risk of severe infections including COVID-19 due to an immune dysregulation affecting both innate and adaptive immune responses. However, our understanding of the immune responses to infection and vaccination in MM patients is limited. To gain more detailed insights into infection- and vaccine-elicited T cell immunity in MM, we studied the CD8+ T cell response on the single-epitope level in SARS-CoV-2 convalescent and mRNA-vaccinated MM patients. Methods: We compared peptide/MHC class I tetramer-enriched SARS-CoV-2-specific CD8+ T cells and antibody responses in MM patients (convalescent: n = 16, fully vaccinated: n = 5, vaccinated convalescent: n = 5) and healthy controls (HCs) (convalescent: n = 58, fully vaccinated: n = 7) either after infection with SARS-CoV-2 alone, complete mRNA vaccination or SARS-CoV-2 infection and single-shot mRNA vaccination (hybrid immunity). Results: MM patients have lower frequencies and a lower proportion of fully ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.18725/oparu-54585 |
| الاتاحة: | https://dx.doi.org/10.18725/oparu-54585 https://oparu.uni-ulm.de//handle/123456789/54661 |
| Rights: | Creative Commons Attribution 4.0 International ; CC BY 4.0 International ; https://creativecommons.org/licenses/by/4.0/legalcode ; cc-by-4.0 |
| رقم الانضمام: | edsbas.E73F0747 |
| قاعدة البيانات: | BASE |
| DOI: | 10.18725/oparu-54585 |
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