Academic Journal
Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents
| العنوان: | Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents |
|---|---|
| المؤلفون: | Mohd Moklas, Mohamad Aris, Suliman, Noor Azuin, Mat Taib, Che Norma, Baharuldin, Mohamad Taufik Hidayat, Fakurazi, Sharida, Zakaria, Fatin Nadzirah, Muhamamd Yusof, Muhammad Khairulasraf, Adzhar, Muhammad Farhan, Md Rasul, Mohd Saifuddin, Md Akim, Abdah, Amom, Zulkhairi |
| بيانات النشر: | David Publishing |
| سنة النشر: | 2013 |
| المجموعة: | Universiti Putra Malaysia: PSAS (Perpuskataan Sultan Abuld Samad) Institutional Repository |
| الوصف: | Mitragyna speciosa, a plant from Rubiaceae family, was reported to have an opium-like effect and their coca-like stimulative ability to combat fatigue and enhance tolerance to hard work. There are lack of information regarding to the effect of Mitragyna speciosa on cognitive and behavioural performances. Therefore the project was conducted to observe the effect of Mitragyna speciosa on cognitive behavior of rats and mice. Mitragyna speciosa in methanol extract form and aqueous extract form with same dosage distributions were used; 10 mg/kg, 30 mg/kg, and 100 mg/kg. Four tests were conducted to observe the behavioural changes of the animal namely locomotor, cognitive performances, anxiety and rotarod performance. Results showed that all dosage of treatment reduced locomotor and impaired cognitive performance significantly. Study showed that Mitragyna speciosa induce sedative effect in dose dependant manner. Interestingly, Mitragyna speciosa increased the time spent in open arm of plus maze indicating low anxiety level of the rodent. As conclusion, Mitragyna speciosa caused sedative effect, impairment in working memory, and possess anxiolytic properties. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://psasir.upm.edu.my/id/eprint/29705/1/Sedative,%20cognitive%20impairment%20and%20anxiolytic%20effects%20of%20acute%20Mitragyna%20speciosa%20in%20rodents.pdf; Mohd Moklas, Mohamad Aris and Suliman, Noor Azuin and Mat Taib, Che Norma and Baharuldin, Mohamad Taufik Hidayat and Fakurazi, Sharida and Zakaria, Fatin Nadzirah and Muhamamd Yusof, Muhammad Khairulasraf and Adzhar, Muhammad Farhan and Md Rasul, Mohd Saifuddin and Md Akim, Abdah and Amom, Zulkhairi (2013) Sedative, cognitive impairment and anxiolytic effects of acute Mitragyna speciosa in rodents. Journal of US-China Medical Science, 10 (1-2). pp. 37-44. ISSN 1548-6648; ESSN: 1930-2088 |
| الاتاحة: | http://psasir.upm.edu.my/id/eprint/29705/ http://psasir.upm.edu.my/id/eprint/29705/1/Sedative,%20cognitive%20impairment%20and%20anxiolytic%20effects%20of%20acute%20Mitragyna%20speciosa%20in%20rodents.pdf http://davidpublishing.com/show.html?13858 |
| رقم الانضمام: | edsbas.E7156E0 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |