Academic Journal
The Reliability of Patient-Performed Fecal Calprotectin Testing in Inflammatory Bowel Disease
| العنوان: | The Reliability of Patient-Performed Fecal Calprotectin Testing in Inflammatory Bowel Disease |
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| المؤلفون: | Dijkhuis, Lies E. J. L., Crouwel, Femke, Duijvestein, Marjolijn, Buiter, Hans J. C., de Boer, Nanne K., Hamer, Henrike M. |
| المصدر: | Dijkhuis , L E J L , Crouwel , F , Duijvestein , M , Buiter , H J C , de Boer , N K & Hamer , H M 2023 , ' The Reliability of Patient-Performed Fecal Calprotectin Testing in Inflammatory Bowel Disease ' , the Journal of Applied Laboratory Medicine , vol. 8 , no. 2 , pp. 319-329 . https://doi.org/10.1093/jalm/jfac078 |
| سنة النشر: | 2023 |
| الوصف: | BACKGROUND: Home use of a buffer-containing extraction device for fecal calprotectin determination can bypass the labor-intensive extraction procedure and potentially prevent degradation at room temperature. METHODS: In this prospective cross-sectional observational study, 2 CALiaGold tubes (extraction device) and one native tube were filled from the same bowel movement by patients with inflammatory bowel disease. Afterwards patients completed a questionnaire including whether they preferred the extraction device or the normal sampling method. All tubes were sent to the laboratory and when they arrived, 2 more CALiaGold tubes were filled at the laboratory from the native sample. The fecal calprotectin concentrations in all tubes were measured by a particle-enhanced turbidimetric immunoassay. RESULTS: Fifty-three patients were included in the study. Fecal calprotectin levels were significantly higher in samples extracted by the patient compared to the analyst-performed extractions. When patients were divided into 3 groups (i.e., fecal calprotectin levels <50 ug/g, 50 to 200 µg/g, and >200 µg/g) a substantial concordance was found (Cohen kappa 0.654). Patients sampling imprecision was higher (P < 0.018, median CV 16%) compared to the analyst. Most patients preferred this extraction device. CONCLUSIONS: Patient-performed fecal calprotectin extraction seems a realistic alternative sampling method and is preferred by most patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/jalm/jfac078 |
| الاتاحة: | https://research.vumc.nl/en/publications/068d365c-24db-4c67-8317-e47a47ed1119 https://doi.org/10.1093/jalm/jfac078 https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85150000622&origin=inward https://www.ncbi.nlm.nih.gov/pubmed/36512478 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E7127C3C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/jalm/jfac078 |
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