Academic Journal
FGF Activation and Signaling in Breast Cancer
| العنوان: | FGF Activation and Signaling in Breast Cancer |
|---|---|
| المؤلفون: | Swift, Matthew R. |
| المساهمون: | GEORGETOWN UNIV WASHINGTON DC |
| المصدر: | DTIC |
| سنة النشر: | 2005 |
| المجموعة: | Defense Technical Information Center: DTIC Technical Reports database |
| مصطلحات موضوعية: | Medicine and Medical Research, PROTEINS, FIBROBLASTS, BREAST CANCER, GENES, HYPOTHESES, ANGIOGENESIS, CELLS(BIOLOGY), MAMMARY GLANDS, GROWTH(PHYSIOLOGY), SIGNAL TRANSDUCTION, OVEREXPRESSION |
| الوصف: | Fibroblast growth factor binding protein (FGF-BP1) is a crucial molecule that acts to chaperone active FGFs to receptors, thus propagating angiogenic signals for the development of new vasculature. We have shown that FGF-BP1 is expressed in head and neck, skin, cervical, and lung squamous cell carcinomas. A second family member, FGF-BP2 has been identified in our lab and is present in mammary tissue. In this grant, we hypothesized that FGF-BP2 acts in a similar pro-angiogenic capacity as FGF-BP1. The aims were to produce recombinant FGF-BP2 and test its effect on signal transduction, and to study the expression of FGF-BP2 during mouse mammary gland development and carcinogenesis. To date, we have isolated human FGF-BP2 cDNA and protein and confirmed its ability to modulate FGF2. However, we have yet to discover the murine homologue to FGF-BP2. We have identified a third family member, FGF-BP3 in human and mouse. Accordingly, we have adjusted our focus to the characterization of FGF-BP3 activity and expression while continuing our search for murine FGF-BP2. Both human and murine FGF-BP3 have been shown to bind FGF2, promote increased proliferation, MAPK activation, and anchorage-independent growth in SW-13 adrenal carcinoma cells, and murine FGF-BP3 is present in high levels at specific time points in embryonic tissue. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://www.dtic.mil/docs/citations/ADA442267 |
| الاتاحة: | http://www.dtic.mil/docs/citations/ADA442267 http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA442267 |
| Rights: | Approved for public release; distribution is unlimited. |
| رقم الانضمام: | edsbas.E70F7945 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |