Academic Journal
Proteomics identifies complement protein signatures in patients with alcohol- associated hepatitis
| العنوان: | Proteomics identifies complement protein signatures in patients with alcohol- associated hepatitis |
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| المؤلفون: | Taiwo, Moyinoluwa T, Huang, Emily, Pathak, Vai, Bellar, Annette, Welch, Nicole, Dasarathy, Jaividhya, Streem, David, McClain, Craig J, Mitchell, Mack C, Barton, Bruce A, Szabo, Gyongyi, Dasarathy, Srinivasan, Schaefer, Esperance A, Luther, Jay, Day, Le Z, Ouyang, Xinshou, Arumugam, Suyavaran, Mehal, Wajahat Z, Jacobs, Jon M, Goodman, Russell P, Rotroff, Daniel M, Nagy, Laura E |
| المساهمون: | Biostatistics and Health Services Research, Population and Quantitative Health Sciences |
| المصدر: | JCI insight ; United States |
| سنة النشر: | 2024 |
| المجموعة: | University of Massachusetts, Medical School: eScholarship@UMMS |
| مصطلحات موضوعية: | Complement, Diagnostics, Hepatitis, Hepatology |
| الوصف: | Diagnostic challenges continue to impede development of effective therapies for successful management of alcohol-associated hepatitis (AH), thus creating an unmet need to identify and develop non-invasive biomarkers for AH. In murine models of ethanol-induced liver injury, complement activation contributes to hepatic inflammation and injury. Therefore, we hypothesized that complement proteins could be rational diagnostic/prognostic biomarkers in AH. Here, we performed a comparative analysis of data derived from the human hepatic and serum proteome to identify and characterize complement protein signatures in severe AH (sAH). The quantity of multiple complement proteins was perturbed in liver and serum proteome of patients with sAH. Multiple complement proteins differentiated patients with sAH from those with alcohol cirrhosis (AC), alcohol use disorder (AUD) and healthy controls (HCs). Notably, serum collectin 11 and C1q binding protein were strongly associated with sAH and exhibited good discriminatory performance amongst patients with sAH, AC, AUD, and HCs. Furthermore, complement component receptor 1-like protein (CR1L) was negatively associated with pro-inflammatory cytokines. Additionally, lower serum mannose-binding lectin associated serine protease 1 and coagulation factor II were associated with and independently predicted 90-day mortality. In summary, meta-analysis of proteomic profiles from liver and circulation revealed complement protein signatures of sAH, highlighting a complex perturbation of complement and identifying potential diagnostic and prognostic biomarkers for patients with sAH. |
| نوع الوثيقة: | text |
| اللغة: | English |
| تدمد: | 2379-3708 38573776 |
| Relation: | JCI Insight; https://doi.org/10.1172/jci.insight.174127; Taiwo M, Huang E, Pathak V, Bellar A, Welch N, Dasarathy J, Streem D, McClain CJ, Mitchell MC, Barton BA, Szabo G, Dasarathy S; Alcohol Hepatitis Network (AlcHepNet) Consortium; Schaefer EA, Luther J, Day LZ, Ouyang X, Suyavaran A, Mehal WZ, Jacobs JM, Goodman RP, Rotroff DM, Nagy LE. Proteomics identifies complement protein signatures in patients with alcohol-associated hepatitis. JCI Insight. 2024 Apr 4;9(9):e174127. doi:10.1172/jci.insight.174127. PMID: 38573776; PMCID: PMC11141929.; http://hdl.handle.net/20.500.14038/53299 |
| DOI: | 10.1172/jci.insight.174127 |
| الاتاحة: | https://doi.org/10.1172/jci.insight.174127 https://hdl.handle.net/20.500.14038/53299 |
| Rights: | Copyright © 2024, Taiwo et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.; Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.E70A3162 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 23793708 38573776 |
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| DOI: | 10.1172/jci.insight.174127 |