Academic Journal
The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+ T cells
| العنوان: | The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective CD8+ T cells |
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| المؤلفون: | Moalli F., Ficht X., Germann P., Vladymyrov M., Stolp B., De Vries I., Lyck R., Balmer J., Fiocchi A., Kreutzfeldt M., Merkler D., Iannacone M., Ariga A., Stoffel M. H., Sharpe J., Bahler M., Sixt M., Diz-Munoz A., Stein J. V. |
| المساهمون: | Moalli, F., Ficht, X., Germann, P., Vladymyrov, M., Stolp, B., De Vries, I., Lyck, R., Balmer, J., Fiocchi, A., Kreutzfeldt, M., Merkler, D., Iannacone, M., Ariga, A., Stoffel, M. H., Sharpe, J., Bahler, M., Sixt, M., Diz-Munoz, A., Stein, J. V. |
| بيانات النشر: | Rockefeller University Press |
| سنة النشر: | 2018 |
| الوصف: | T cells are actively scanning pMHC-presenting cells in lymphoid organs and nonlymphoid tissues (NLTs) with divergent topologies and confinement. How the T cell actomyosin cytoskeleton facilitates this task in distinct environments is incompletely understood. Here, we show that lack of Myosin IXb (Myo9b), a negative regulator of the small GTPase Rho, led to increased Rho-GTP levels and cell surface stiffness in primary T cells. Nonetheless, intravital imaging revealed robust motility of Myo9b−/− CD8+ T cells in lymphoid tissue and similar expansion and differentiation during immune responses. In contrast, accumulation of Myo9b−/− CD8+ T cells in NLTs was strongly impaired. Specifically, Myo9b was required for T cell crossing of basement membranes, such as those which are present between dermis and epidermis. As consequence, Myo9b−/− CD8+ T cells showed impaired control of skin infections. In sum, we show that Myo9b is critical for the CD8+ T cell adaptation from lymphoid to NLT surveillance and the establishment of protective tissue–resident T cell populations. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000440822900011; volume:215; issue:7; firstpage:1869; lastpage:1890; numberofpages:22; journal:JOURNAL OF EXPERIMENTAL MEDICINE; http://hdl.handle.net/20.500.11768/109095 |
| DOI: | 10.1084/jem.20170896 |
| الاتاحة: | https://hdl.handle.net/20.500.11768/109095 https://doi.org/10.1084/jem.20170896 |
| رقم الانضمام: | edsbas.E70A1C7D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1084/jem.20170896 |
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