Academic Journal
DNA methylation‐based biomarkers for ageing long‐lived cetaceans
| العنوان: | DNA methylation‐based biomarkers for ageing long‐lived cetaceans |
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| المؤلفون: | Parsons, Kim M., Haghani, Amin, Zoller, Joseph A., Lu, Ake T., Fei, Zhe, Ferguson, Steven H., Garde, Eva, Hanson, M. Bradley, Emmons, Candice K., Matkin, Craig O., Young, Brent G., Koski, William R., Horvath, Steve |
| المساهمون: | Paul G. Allen Family Foundation |
| المصدر: | Molecular Ecology Resources ; volume 23, issue 6, page 1241-1256 ; ISSN 1755-098X 1755-0998 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Epigenetic approaches for estimating the age of living organisms are revolutionizing studies of long‐lived species. Molecular biomarkers that allow age estimates from small tissue biopsies promise to enhance studies of long‐lived whales, addressing a fundamental and challenging parameter in wildlife management. DNA methylation (DNAm) can affect gene expression, and strong correlations between DNAm patterns and age have been documented in humans and nonhuman vertebrates and used to construct “epigenetic clocks”. We present several epigenetic clocks for skin samples from two of the longest‐lived cetaceans, killer whales and bowhead whales. Applying the mammalian methylation array to genomic DNA from skin samples we validate four different clocks with median errors of 2.3–3.7 years. These epigenetic clocks demonstrate the validity of using cytosine methylation data to estimate the age of long‐lived cetaceans and have broad applications supporting the conservation and management of long‐lived cetaceans using genomic DNA from remote tissue biopsies. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/1755-0998.13791 |
| الاتاحة: | http://dx.doi.org/10.1111/1755-0998.13791 https://onlinelibrary.wiley.com/doi/pdf/10.1111/1755-0998.13791 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.E68BC5E2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/1755-0998.13791 |
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