Academic Journal
Combination of 68Ga-PSMA PET/CT and multiparametric MRI improves the detection of clinically significant prostate cancer: A lesion-by-lesion analysis
| العنوان: | Combination of 68Ga-PSMA PET/CT and multiparametric MRI improves the detection of clinically significant prostate cancer: A lesion-by-lesion analysis |
|---|---|
| المؤلفون: | Chen M., Zhang Q., Zhang C., Zhao X., Marra G., Gao J., Lv X., Zhang B., Fu Y., Wang F., Qiu X., Guo H. |
| المساهمون: | Chen M., Zhang Q., Zhang C., Zhao X., Marra G., Gao J., Lv X., Zhang B., Fu Y., Wang F., Qiu X., Guo H. |
| سنة النشر: | 2019 |
| المجموعة: | Università degli studi di Torino: AperTo (Archivio Istituzionale ad Accesso Aperto) |
| مصطلحات موضوعية: | Ga-PSMA PET/CT, Clinically significant prostate cancer, Combination, Multiparametric MRI, Aged, 80 and over, Gallium Isotope, Gallium Radioisotope, Human, Image Processing, Computer-Assisted, Male, Middle Aged, Prostatic Neoplasm, Retrospective Studie, Membrane Glycoprotein, Multiparametric Magnetic Resonance Imaging, Organometallic Compound, Positron Emission Tomography Computed Tomography |
| Time: | 68 |
| الوصف: | Our purpose was to explore whether 68Ga-PSMA PET/CT alone (PET/CT) or in combination with multiparametric MRI (PET/MRI) can improve the detection of clinically significant prostate cancer (PCa). Methods: We retrospectively enrolled 54 patients who underwent both MRI and PET/CT before radical prostatectomy. Regions of interest on MR images, PET/CT images, and pathologic images were marked. A lesion was defined as a region of interest marked on images obtained with any of the 3 modalities. All lesions were characterized using the prostate imaging reporting and data system (PI-RADS), the molecular imaging PSMA expression score, and the pathologic results and analyzed. Diagnostic performance was analyzed by receiver-operating-characteristic analysis. Specific improvement for lesions with different PI-RADS scores was analyzed using the net reclassification index (NRI). Results: In total, 90 lesions from 54 patients were analyzed, among which 66 lesions represented clinically significant PCa. Receiver-operating-characteristic analysis showed PET/MRI to perform better than MRI in detecting clinically significant PCa (change in area under the curve, 0.06; 95% confidence interval, 0.01-0.12; P, 0.05). With the calculated cutoff, PET/MRI performed significantly better than MRI (NRI, 21.9%; P, 0.01), with an improvement in sensitivity (89% vs. 76%, P, 0.01) at no sacrifice of specificity (96% vs. 88%, P. 0.05). Improvement in diagnosing clinically significant PCa occurred for lesions classified as PI-RADS 3 (NRI, 66.7%; P, 0.01). Conclusion: PET/MRI improves the detection of clinically significant PCa for PI-RADS 3 lesions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/30552201; info:eu-repo/semantics/altIdentifier/wos/WOS:000473327300031; volume:60; issue:7; firstpage:944; lastpage:949; numberofpages:6; journal:THE JOURNAL OF NUCLEAR MEDICINE; http://hdl.handle.net/2318/1827948; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85067860430 |
| DOI: | 10.2967/jnumed.118.221010 |
| الاتاحة: | http://hdl.handle.net/2318/1827948 https://doi.org/10.2967/jnumed.118.221010 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E684E39F |
| قاعدة البيانات: | BASE |
| DOI: | 10.2967/jnumed.118.221010 |
|---|