Academic Journal
Base Excision DNA Repair in Plants: Arabidopsis and Beyond
| العنوان: | Base Excision DNA Repair in Plants: Arabidopsis and Beyond |
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| المؤلفون: | Inga R. Grin, Daria V. Petrova, Anton V. Endutkin, Chunquan Ma, Bing Yu, Haiying Li, Dmitry O. Zharkov |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 14746, p 14746 (2023) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | DNA damage, DNA repair, base excision repair, plants, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Base excision DNA repair (BER) is a key pathway safeguarding the genome of all living organisms from damage caused by both intrinsic and environmental factors. Most present knowledge about BER comes from studies of human cells, E. coli , and yeast. Plants may be under an even heavier DNA damage threat from abiotic stress, reactive oxygen species leaking from the photosynthetic system, and reactive secondary metabolites. In general, BER in plant species is similar to that in humans and model organisms, but several important details are specific to plants. Here, we review the current state of knowledge about BER in plants, with special attention paid to its unique features, such as the existence of active epigenetic demethylation based on the BER machinery, the unexplained diversity of alkylation damage repair enzymes, and the differences in the processing of abasic sites that appear either spontaneously or are generated as BER intermediates. Understanding the biochemistry of plant DNA repair, especially in species other than the Arabidopsis model, is important for future efforts to develop new crop varieties. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/24/19/14746; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/da87a3b1d3e849e880c3a1c72de2086b |
| DOI: | 10.3390/ijms241914746 |
| الاتاحة: | https://doi.org/10.3390/ijms241914746 https://doaj.org/article/da87a3b1d3e849e880c3a1c72de2086b |
| رقم الانضمام: | edsbas.E6131570 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms241914746 |