Academic Journal
Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia
| العنوان: | Accuracy of citrulline, I-FABP and d-lactate in the diagnosis of acute mesenteric ischemia |
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| المؤلفون: | Nuzzo, A, Guedj, K, Curac, S, Hercend, C, Bendavid, C, Gault, N, Tran-Dinh, A, Ronot, M, Nicoletti, A, Bouhnik, Y, Castier, Y, Corcos, O, Peoc’h, K, Huguet, A, Stefanescu, C, Treton, X, Joly, F, Billiauws, L, Hamon, A, Boitet, A, Lekhal, C, Deutsch, D, Oiknin, E, Cohen, L, Marcellier, G, Senemaud, J, Corre, F, Soudan, D, Voican, C, Leclère, JB, Iquilles, J, Raynaud, L, Paulatto, L, Haas, M, Uzzan, M, Cohen, M, Tadbiri, S, Prevot, S, Panis, Y, Frontali, A, Msika, S, Ribeiro, L, Rebibo, L, Arapis, K, Orville, M, Sibert, A, Copin, P, Zappa, M, Dioguardi Burgio, M, Vilgrain, V, Bertin, C, Kerbaol, A, Allaham, W, Pellenc, Q, Roussel, A, Cerceau, P, Ben Abdallah, I, Girault, A, Mordant, P, De Blic, R, Paugam, C, Weiss, E, Abback, PS, Enriquez, I, Janny, S, Bout, H, Giabicani, M, Achouf, M, Grigoresco, B, Ear, LK, Cachier, A, Plessier, A, Rautou, PE, Valla, D, Payancé, A, Sauvanet, A, Dokmak, S, Dondero, F, Sepulveda, A, Farges, O, Aussilhou, B, Jais, B, Cazals-Hatem, D, De Raucourt, E, Boudaoud, L, Trichet, C, Puy, H, Pons-Kerjean, N, Stocco, J, Bataille, J, Bouton, V, Montravers, P, Augustin, P, Lortat Jacob, B, Michel, JB, Gauguier, D, Dumas, ME, Brial, F, Myridakis, A, The SURVI (Structure d’URgences Vasculaires Intestinales) Research Group (French Intestinal Stroke Center) |
| المساهمون: | The SURVI (Structure d’URgences Vasculaires Intestinales) Research Group (French Intestinal Stroke Center) |
| بيانات النشر: | Springer Nature |
| سنة النشر: | 2021 |
| المجموعة: | Brunel University London: Brunel University Research Archive (BURA) |
| مصطلحات موضوعية: | biomarkers, cardiology, diseases, gastroenterology |
| الوصف: | Data availability: Research data are not shared. ; Supplementary Information oi available online at: https://www.nature.com/articles/s41598-021-98012-w#Sec14 . ; Early diagnosis of acute mesenteric ischemia (AMI) remains a clinical challenge, and no biomarker has been consistently validated. We aimed to assess the accuracy of three promising circulating biomarkers for diagnosing AMI—citrulline, intestinal fatty acid-binding protein (I-FABP), and D-lactate. A cross-sectional diagnostic study enrolled AMI patients admitted to the intestinal stroke center and controls with acute abdominal pain of another origin. We included 129 patients—50 AMI and 79 controls. Plasma citrulline concentrations were significantly lower in AMI patients compared to the controls [15.3 μmol/L (12.0–26.0) vs. 23.3 μmol/L (18.3–29.8), p = 0.001]. However, the area under the receiver operating curves (AUROC) for the diagnosis of AMI by Citrulline was low: 0.68 (95% confidence interval = 0.58–0.78). No statistical difference was found in plasma I-FABP and plasma D-lactate concentrations between the AMI and control groups, with an AUROC of 0.44, and 0.40, respectively. In this large cross-sectional study, citrulline, I-FABP, and D-lactate failed to differentiate patients with AMI from patients with acute abdominal pain of another origin. Further research should focus on the discovery of new biomarkers. ; Grants from MSD-Avenir and APHP funded the SURVIBIO study; Alexandre Nuzzo received Ph.D. Grants from “Fondation de l'Avenir” and the French Gastroenterology Society (SNFGE). |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1 - 10 |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | Scientific Reports; ORCiD: Antonis Myridakis orcid:0000-0003-1690-6651; 18929; Nuzzo, A. et al on behalf of the The SURVI (Structure d’URgences Vasculaires Intestinales) Research Group (French Intestinal Stroke Center) (2021) Scientific Reports, 11, 18929, pp. 1 - 10. doi: .10.1038/s41598-021-98012-w.; https://bura.brunel.ac.uk/handle/2438/28990; https://doi.org/10.1038/s41598-021-98012-w |
| DOI: | 10.1038/s41598-021-98012-w |
| الاتاحة: | https://bura.brunel.ac.uk/handle/2438/28990 https://doi.org/10.1038/s41598-021-98012-w |
| Rights: | Copyright © The Author(s) 2021. Rights and permissions: Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit https://creativecommons.org/licenses/by/4.0/. ; https://creativecommons.org/licenses/by/4.0/ ; https://creativecommons.org/licenses/by/4.0/legalcode.en ; The Author(s) |
| رقم الانضمام: | edsbas.E5FAF732 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-021-98012-w |