Academic Journal
Design, synthesis, and preliminary bioactivity evaluation of N‐benzylpyrimidin‐2‐amine derivatives as novel histone deacetylase inhibitor
| العنوان: | Design, synthesis, and preliminary bioactivity evaluation of N‐benzylpyrimidin‐2‐amine derivatives as novel histone deacetylase inhibitor |
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| المؤلفون: | Zhou, Yi, Dun, Yanyan, Fu, Huansheng, Wang, Lei, Pan, Xiaole, Yang, Xinying, Fang, Hao |
| المساهمون: | National Natural Science Foundation of China |
| المصدر: | Chemical Biology & Drug Design ; volume 90, issue 5, page 936-942 ; ISSN 1747-0277 1747-0285 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2017 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Histone deacetylase (HDAC) inhibitors have been identified for the treatment of cancer. Lately, we designed and synthesized a series of substituted N ‐benzylpyrimidin‐2‐amine derivatives as potent HDAC inhibitors. In vitro HDAC inhibitory activities and antiproliferative activities of target compounds were investigated. Some target compounds showed potent HDAC inhibitory activities and possessed obvious antiproliferative activity against tumor cells. Target compounds 6a , 6d , 8a , 8c, and 8f not only exhibited almost equally enzymatic inhibitory activity with SAHA , but showed better antiproliferative activities. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/cbdd.13019 |
| الاتاحة: | http://dx.doi.org/10.1111/cbdd.13019 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fcbdd.13019 https://onlinelibrary.wiley.com/doi/pdf/10.1111/cbdd.13019 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.E5E32D7F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/cbdd.13019 |
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