Book
Epigenetics in Parkinson's Disease
| العنوان: | Epigenetics in Parkinson's Disease |
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| المؤلفون: | Pavlou, Maria Angeliki, Outeiro, Tiago |
| المصدر: | Neuroepigenomics in Aging and Disease (2017-05) |
| بيانات النشر: | Springer |
| سنة النشر: | 2017 |
| المجموعة: | University of Luxembourg: ORBilu - Open Repository and Bibliography |
| مصطلحات موضوعية: | Life sciences, Genetics & genetic processes, Sciences du vivant, Génétique & processus génétiques |
| الوصف: | peer reviewed ; Parkinson's disease (PD) is a highly complex neurodegenerative disorder with a multifactorial origin. Although several cellular mechanisms and genes have been implicated in the onset and progression of the disease, the precise molecular underpinnings of the disease remain unclear. In this context, epigenetic modulation of gene expression by environmental factors is emerging as an important mechanism in PD and in other neurodegenerative disorders. Thus, epigenetic mechanisms, such as DNA methylation, histone modifications and altered microRNA expression, have been under intense investigation due to their possible involvement in PD. Epigenetic modulation is responsible for inducing differential gene expression, a phenomenon which is essential throughout life in order to regulate multiple cellular responses such as development, cellular fate commitment and adaptation to the environment. Disturbances of a balanced gene expression can, therefore, have detrimental effects. Environmental factors can challenge the establishment and maintenance of epigenetic modifications and could thereby fill the gap in our further understanding of origin and/or progression of neurodegenerative diseases. In this chapter, we focus on the role of epigenetics in PD. |
| نوع الوثيقة: | book part |
| اللغة: | English |
| Relation: | https://orbilu.uni.lu/handle/10993/38079; info:hdl:10993/38079; info:pmid:28523556; wos:000438240500019 |
| DOI: | 10.1007/978-3-319-53889-1_19 |
| الاتاحة: | https://orbilu.uni.lu/handle/10993/38079 https://doi.org/10.1007/978-3-319-53889-1_19 |
| Rights: | restricted access ; http://purl.org/coar/access_right/c_16ec ; info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.E5CA1A09 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/978-3-319-53889-1_19 |
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