Academic Journal
Transmission of ‘Candidatus Anaplasma camelii’ to mice and rabbits by camel-specific keds, Hippobosca camelina
| العنوان: | Transmission of ‘Candidatus Anaplasma camelii’ to mice and rabbits by camel-specific keds, Hippobosca camelina |
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| المؤلفون: | Bargul, Joel L., Kidambasi, Kevin O., Getahun, Merid N., Villinger, Jandouwe, Copeland, Robert S., Muema, Jackson M., Carrington, Mark, Masiga, Daniel K. |
| المساهمون: | Gillespie, Joseph James, deltas africa initiative, wellcome trust, international foundation for science, cambridge-africa alborada fund, the global challenges research fund, uk’s foreign, commonwealth & development office, swedish international development cooperation agency, swiss agency for development and cooperation, federal democratic republic of ethiopia, government of the republic of kenya |
| المصدر: | PLOS Neglected Tropical Diseases ; volume 15, issue 8, page e0009671 ; ISSN 1935-2735 |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2021 |
| المجموعة: | PLOS Publications (via CrossRef) |
| الوصف: | Anaplasmosis, caused by infection with bacteria of the genus Anaplasma , is an important veterinary and zoonotic disease. Transmission by ticks has been characterized but little is known about non-tick vectors of livestock anaplasmosis. This study investigated the presence of Anaplasma spp. in camels in northern Kenya and whether the hematophagous camel ked, Hippobosca camelina , acts as a vector. Camels ( n = 976) and > 10,000 keds were sampled over a three-year study period and the presence of Anaplasma species was determined by PCR-based assays targeting the Anaplasmataceae 16S rRNA gene. Camels were infected by a single species of Anaplasma , ‘Candidatus Anaplasma camelii ’ , with infection rates ranging from 63–78% during the dry (September 2017), wet (June-July 2018), and late wet seasons (July-August 2019). 10–29% of camel keds harbored ‘ Ca . Anaplasma camelii’ acquired from infected camels during blood feeding. We determined that Anaplasma -positive camel keds could transmit ‘ Ca . Anaplasma camelii’ to mice and rabbits via blood-feeding. We show competence in pathogen transmission and subsequent infection in mice and rabbits by microscopic observation in blood smears and by PCR. Transmission of ‘ Ca . Anaplasma camelii’ to mice (8–47%) and rabbits (25%) occurred readily after ked bites. Hence, we demonstrate, for the first time, the potential of H . camelina as a vector of anaplasmosis. This key finding provides the rationale for establishing ked control programmes for improvement of livestock and human health. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1371/journal.pntd.0009671 |
| الاتاحة: | http://dx.doi.org/10.1371/journal.pntd.0009671 https://dx.plos.org/10.1371/journal.pntd.0009671 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.E5A258EF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pntd.0009671 |
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