Academic Journal
Clinical and polysomnographic evaluation of sleep-related breathing disorders in patients with sarcoidosis
| العنوان: | Clinical and polysomnographic evaluation of sleep-related breathing disorders in patients with sarcoidosis |
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| المؤلفون: | Ataoğlu, Özlem, Annakkaya, Ali Nihat, Arbak, Peri Meram, Yıldız Gülhan, Pınar, Elverişli, Mehmet Fatih |
| بيانات النشر: | Springer Heidelberg |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Sarcoidosis, Obstructive Sleep Apnea, Polysomnography, Sleep Questionnaires, Excessive Daytime Sleepiness, Apnea, Involvement, Predictors, Fatigue, Volume |
| الوصف: | Objective This study aimed to evaluate the frequency of obstructive sleep apnea (OSA) in patients with sarcoidosis and related clinical factors. Materials and method Consecutive patients diagnosed with sarcoidosis in our clinic were evaluated for OSA risk during sleep using the Epworth Sleepiness Scale, Stanford Sleepiness Scale, Pittsburgh Sleep Quality Index, Berlin questionnaire, STOP and STOP-BANG questionnaires, and polysomnography (PSG). Results A total of 60 sarcoidosis patients (mean age: 50 +/- 11 years, 45 (75%) women) were included in the study. Polysomnography was performed in 54 cases and revealed the diagnosis of OSA in 70% (38/54) of the patients. The mean age was higher in patients with sarcoidosis and OSA (54 +/- 11 vs. 47 +/- 13, p = 0.041) and body mass index values were significantly higher as well (31.9 +/- 4.4 vs, 29.0 +/- 4.6 kg/m(2), p = 0.034). Polysomnography revealed a higher rate of OSA in patients with sarcoidosis who had high-risk scores in Pittsburgh Sleep Quality Index, STOP questionnaire, and STOP-BANG questionnaire (p = 0.024, p < 0.001, and p < 0.001, respectively). Based on polysomnography, OSA was detected in 39% (5/13) with stage 1 sarcoidosis, 78% (28/36) with stage 2, and in all cases (5/5) with stage 3. OSA frequency and apnea-hypopnea index (AHI) were determined to increase with advanced sarcoidosis stage (p = 0.003, p = 0.043, respectively). AHI was positively correlated with sarcoidosis stage (p = 0.003, r = 0.391). The prevalence of OSA was significantly higher in patients receiving treatment compared to treatment-naive patients (88% vs. 57%, p = 0.018). Multivariate logistic regression analysis revealed the stage of the disease (p = 0.026) to be the single independent risk factor associated with increased risk of OSA in patients with sarcoidosis. Conclusion High rates of OSA were detected in sarcoidosis, increasing with the advanced disease stage. The findings suggest that patients with sarcoidosis and advanced age, obesity, steroid treatment, and involvement ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1520-9512 1522-1709 |
| Relation: | Sleep and Breathing; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1007/s11325-021-02513-x; https://hdl.handle.net/20.500.12684/12636; 26; 1847; 1855; 2-s2.0-85123940198; WOS:000750627700001 |
| DOI: | 10.1007/s11325-021-02513-x |
| الاتاحة: | https://hdl.handle.net/20.500.12684/12636 https://doi.org/10.1007/s11325-021-02513-x |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.E59CFEB4 |
| قاعدة البيانات: | BASE |
| تدمد: | 15209512 15221709 |
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| DOI: | 10.1007/s11325-021-02513-x |