Academic Journal
Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients
| العنوان: | Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients |
|---|---|
| المؤلفون: | Gervais, Adrian, Rovida, Francesca, Avanzini, Maria, Antonietta, Croce, Stefania, Marchal, Astrid, Lin, Shih-Ching, Ferrari, Alessandro, Thorball, Christian, W, Constant, Orianne, Le Voyer, Tom, Philippot, Quentin, Rosain, Jérémie, Angelini, Micol, Pérez Lorenzo, Malena, Bizien, Lucy, Achille, Cristian, Trespidi, Francesca, Burdino, Elisa, Cassaniti, Irene, Lilleri, Daniele, Fornara, Chiara, Sammartino, José, Camilla, Cereda, Danilo, Marrocu, Chiara, Piralla, Antonio, Valsecchi, Chiara, Ricagno, Stefano, Cogo, Paola, Neth, Olaf, Marín-Cruz, Inés, Pacenti, Monia, Sinigaglia, Alessandro, Trevisan, Marta, Volpe, Andrea, Marzollo, Antonio, Conti, Francesca, Lazzarotto, Tiziana, Pession, Andrea, Viale, Pierluigi, Fellay, Jacques, Ghirardello, Stefano, Aubart, Mélodie, Ghisetti, Valeria, Aiuti, Alessandro, Jouanguy, Emmanuelle, Bastard, Paul, Percivalle, Elena, Baldanti, Fausto, Puel, Anne, Macdonald, Margaret, R, Rice, Charles, M, Rossini, Giada, Murray, Kristy, O, Simonin, Yannick, Nagy, Anna, Barzon, Luisa, Abel, Laurent, Diamond, Michael, S, Cobat, Aurélie, Zhang, Shen-Ying, Casanova, Jean-Laurent, Borghesi, Alessandro |
| المساهمون: | Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Pathogenesis and Control of Chronic and Emerging Infections (PCCEI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA)-Etablissement français du don du sang Montpellier -Université de Montpellier (UM), ANR-20-CE93-0003,GENVIR,Analyse multi-omique de l'immunité anti-virale: de l'identification des circuits biologiques pertinents à la découverte de défauts monogéniques héréditaires de l'immunité chez les patients avec infections virales sévères(2020), ANR-22-CE15-0046,AI2D,Autoanticorps anti-interférons et maladies infectieuses associées(2022), ANR-10-IAHU-0001,Imagine,Institut Hospitalo-Universitaire Imagine(2010), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-21-LIBA-0002,AAILC,Autoanticorps contre les interférons de type I chez les patients libanais hospitalisés pour COVID-19.(2021), ANR-21-RHUS-0008,COVIFERON,Covid-19 and interferons: from discovery to therapy(2021) |
| المصدر: | ISSN: 0022-1007. |
| بيانات النشر: | HAL CCSD Rockefeller University Press |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio], [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases |
| الوصف: | International audience ; Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause encephalitis in <1% of infected individuals. We show that ∼35% of patients hospitalized for WNV disease (WNVD) in six independent cohorts from the EU and USA carry auto-Abs neutralizing IFN-α and/or-ω. The prevalence of these antibodies is highest in patients with encephalitis (∼40%), and that in individuals with silent WNV infection is as low as that in the general population. The odds ratios for WNVD in individuals with these auto-Abs relative to those without them in the general population range from 19.0 (95% CI 15.0-24.0, P value <10-15) for auto-Abs neutralizing only 100 pg/ml IFN-α and/or IFN-ω to 127.4 (CI 87.1-186.4, P value <10-15) for auto-Abs neutralizing both IFN-α and IFN-ω at a concentration of 10 ng/ml. These antibodies block the protective effect of IFN-α in Vero cells infected with WNV in vitro. Auto-Abs neutralizing IFN-α and/or IFN-ω underlie ∼40% of cases of WNV encephalitis. . |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1084/jem.20230661 |
| الاتاحة: | https://hal.science/hal-04229658 https://hal.science/hal-04229658v1/document https://hal.science/hal-04229658v1/file/JEM_20230661.pdf https://doi.org/10.1084/jem.20230661 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.E58AE629 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1084/jem.20230661 |
|---|