Academic Journal
Membrane‐bound iron contributes to oxidative damage of β‐thalassaemia intermedia erythrocytes
| العنوان: | Membrane‐bound iron contributes to oxidative damage of β‐thalassaemia intermedia erythrocytes |
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| المؤلفون: | Tavazzi, Dario, Duca, Lorena, Graziadei, Giovanna, Comino, Alessia, Fiorelli, Gemino, Cappellini, Maria Domenica |
| المصدر: | British Journal of Haematology ; volume 112, issue 1, page 48-50 ; ISSN 0007-1048 1365-2141 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2001 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Iron‐dependent oxidative reactions in β‐thalassaemic erythrocyte membranes are involved in premature cell removal and anaemia. We studied 22 β‐thalassaemia intermedia patients (i) to assess if membrane iron accumulation influences the oxidative damage to thalassaemic cells, and (ii) to see whether the mechanisms of haemoglobin destabilization described in vitro have indicators in circulating erythrocytes. Serum non‐transferrin‐bound iron as potentially toxic iron for erythrocytes was also evaluated. Membrane‐bound free iron significantly correlated to bound haemichromes, suggesting a causal relation, but was poorly related to serum non‐transferrin iron, which seems to contribute little to damage from outside the cells. The spleen played an important role in the removal of cells with more membrane iron. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1046/j.1365-2141.2001.02482.x |
| الاتاحة: | http://dx.doi.org/10.1046/j.1365-2141.2001.02482.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1046%2Fj.1365-2141.2001.02482.x https://onlinelibrary.wiley.com/doi/pdf/10.1046/j.1365-2141.2001.02482.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.E5796FE0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1046/j.1365-2141.2001.02482.x |
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