Academic Journal
Gonadal sex vs genetic sex in experimental atherosclerosis
| العنوان: | Gonadal sex vs genetic sex in experimental atherosclerosis |
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| المؤلفون: | Nour, Jasmine, Bonacina, Fabrizia, Norata, Giuseppe D |
| المساهمون: | J. Nour, F. Bonacina, G.D. Norata |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2023 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Experimental atherosclerosi, Inflammation, Lipid, Sexual chromosome, Sexual hormone, Settore BIO/14 - Farmacologia |
| الوصف: | Epidemiological data and interventional studies with hormone replacement therapy suggest that women, at least until menopause, are at decreased cardiovascular risk compared to men. Still the molecular mechanisms beyond this difference are debated and the investigation in experimental models of atherosclerosis has been pivotal to prove that the activation of the estrogen receptor is atheroprotective, despite not enough to explain the differences reported in cardiovascular disease between male and female. This casts also for investigating the importance of the sex chromosome complement (genetic sex) beyond the contribution of sex hormones (gonadal sex) on atherosclerosis. Aim of this review is to present the dualism between gonadal sex and genetic sex with a focus on the data available from experimental models. The molecular mechanisms driving changes in lipid metabolism, immuno-inflammatory reactivity and vascular response in males and females that affect atherosclerosis progression will be discussed. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37775425; info:eu-repo/semantics/altIdentifier/wos/WOS:001106440200001; volume:384; firstpage:1; lastpage:10; numberofpages:10; journal:ATHEROSCLEROSIS; https://hdl.handle.net/2434/1026881; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85173276520 |
| DOI: | 10.1016/j.atherosclerosis.2023.117277 |
| الاتاحة: | https://hdl.handle.net/2434/1026881 https://doi.org/10.1016/j.atherosclerosis.2023.117277 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.E56CBCBD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.atherosclerosis.2023.117277 |
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