Academic Journal
Ventricle contact is associated with lower survival and increased peritumoral perfusion in glioblastoma.
| العنوان: | Ventricle contact is associated with lower survival and increased peritumoral perfusion in glioblastoma. |
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| المؤلفون: | van Dijken, Bart Roelf Jan, Jan van Laar, Peter, Li, Chao, Yan, Jiun-Lin, Boonzaier, Natalie Rosella, Price, Stephen John, FCRS, van der Hoorn, Anouk |
| بيانات النشر: | Journal of Neurosurgery Publishing Group (JNSPG) //doi.org/10.3171/2018.5.jns18340 J Neurosurg |
| سنة النشر: | 2018 |
| المجموعة: | Apollo - University of Cambridge Repository |
| مصطلحات موضوعية: | 5-ALA = 5-aminolevulinic acid, ADC = apparent diffusion coefficient, DWI = diffusion-weighted imaging, FLAIR = fluid-attenuated inversion recovery, FOV = field of view, GBM = glioblastoma, IDH = isocitrate dehydrogenase, MGMT = O6-methylguanine-DNA-methyltransferase, PWI = perfusion-weighted imaging, RANO = Response Assessment in Neuro-Oncology, SVZ = subventricular zone, TE = echo time, TI = inversion time, TR = repetition time, glioblastoma, lateral ventricles, magnetic resonance imaging, oncology, perfusion, rCBV = relative cerebral blood volume, survival, Adult, Aged, Brain Neoplasms, Cerebral Ventricles, Cerebrovascular Circulation, Cohort Studies, Female, Humans, Male |
| الوصف: | OBJECTIVE: The purpose of this study was to prospectively investigate outcome and differences in peritumoral MRI characteristics of glioblastomas (GBMs) that were in contact with the ventricles (ventricle-contacting tumors) and those that were not (noncontacting tumors). GBMs are heterogeneous tumors with variable survival. Lower survival is suggested for patients with ventricle-contacting tumors than for those with noncontacting tumors. This might be supported by aggressive peritumoral MRI features. However, differences in MRI characteristics of the peritumoral environment between ventricle-contacting and noncontacting GBMs have not yet been investigated. METHODS: Patients with newly diagnosed GBM underwent preoperative MRI with contrast-enhanced T1-weighted, FLAIR, diffusion-weighted, and perfusion-weighted sequences. Tumors were categorized into ventricle-contacting or noncontacting based on contrast enhancement. Survival analysis was performed using log-rank for univariate analysis and Cox regression for multivariate analysis. Normalized perfusion (relative cerebral blood volume [rCBV]) and diffusion (apparent diffusion coefficient [ADC]) values were calculated in 2 regions: the peritumoral nonenhancing FLAIR region overlapping the subventricular zone and the remaining peritumoral nonenhancing FLAIR region. RESULTS: Overall survival was significantly lower for patients with contacting tumors than for those with noncontacting tumors (434 vs 747 days, p < 0.001). Progression-free survival showed a comparable trend (260 vs 375 days, p = 0.094). Multivariate analysis confirmed a survival difference for both overall survival (HR 3.930, 95% CI 1.740-8.875, p = 0.001) and progression-free survival (HR 2.506, 95% CI 1.254-5.007, p = 0.009). Peritumoral perfusion was higher in contacting than in noncontacting tumors for both FLAIR regions (p = 0.04). There was no difference in peritumoral ADC values between the 2 groups. CONCLUSIONS: Patients with ventricle-contacting tumors had poorer outcomes than patients with ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Print; application/pdf |
| اللغة: | English |
| Relation: | https://www.repository.cam.ac.uk/handle/1810/279371 |
| DOI: | 10.17863/CAM.26748 |
| الاتاحة: | https://www.repository.cam.ac.uk/handle/1810/279371 https://doi.org/10.17863/CAM.26748 |
| رقم الانضمام: | edsbas.E54DE15E |
| قاعدة البيانات: | BASE |
| DOI: | 10.17863/CAM.26748 |
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