Academic Journal
Campylobacter jejuni Cytolethal Distending Toxin Promotes DNA Repair Responses in Normal Human Cells
| العنوان: | Campylobacter jejuni Cytolethal Distending Toxin Promotes DNA Repair Responses in Normal Human Cells |
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| المؤلفون: | Hassane, Duane C., Lee, Robert B., Pickett, Carol L. |
| المصدر: | Infection and Immunity ; volume 71, issue 1, page 541-545 ; ISSN 0019-9567 1098-5522 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2003 |
| الوصف: | Cytolethal distending toxin (CDT) is a multisubunit protein found in various gram-negative bacterial pathogens of humans which is thought to cause cell death by direct DNA damage of host cells. We sought to determine if a cellular response to DNA damage could be detected by exogenous addition of the holotoxin. Exogenous addition of the Campylobacter jejuni 81-176 CDT to primary human fibroblasts resulted in formation of Rad50 foci, which are formed around double-stranded-DNA breaks. Moreover, such foci are formed in both proliferating and nonproliferating cells that are treated with C. jejuni CDT. Fibroblasts that were intoxicated and later stimulated to proliferate failed to divide and remained arrested in the G 1 phase of the cell cycle. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/iai.71.1.541-545.2003 |
| DOI: | 10.1128/IAI.71.1.541-545.2003 |
| الاتاحة: | http://dx.doi.org/10.1128/iai.71.1.541-545.2003 https://journals.asm.org/doi/pdf/10.1128/IAI.71.1.541-545.2003 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.E5183782 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/iai.71.1.541-545.2003 |
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