Academic Journal
Preoperatively predicting early response of HCC to TACE using clinical indicators and MRI features
| العنوان: | Preoperatively predicting early response of HCC to TACE using clinical indicators and MRI features |
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| المؤلفون: | Li, Zhi-Wei, Ren, A-Hong, Yang, Da-Wei, Xu, Hui, Wei, Jian, Yuan, Chun-Wang, Wang, Zhen-Chang, Yang, Zheng-Han |
| المساهمون: | Research Foundation of Beijing Friendship Hospital, Cultivation Scientific Research Foundation of Capital Medical University, Capital Health Research and Development of Special Fund, Beijing Municipal Science & Technology Commission, Beijing Municipal Health Commission, Special Program of Scientific Research on health development in Beijing, National Natural Science Foundation of China, Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support |
| المصدر: | BMC Medical Imaging ; volume 22, issue 1 ; ISSN 1471-2342 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| الوصف: | Background We aimed to evaluate the value of using preoperative magnetic resonance imaging (MRI) features and clinical indicators to predict the early response of hepatocellular carcinoma (HCC) to transcatheter arterial chemoembolization (TACE). We also aimed to establish a preoperative prediction model. Methods We retrospectively reviewed data of 111 patients with HCC who underwent magnetic resonance imaging (MRI) before the first TACE and underwent MRI or computed tomography between 30 and 60 days after TACE. We used the modified response evaluation criteria in solid tumors for evaluating the TACE response. We used univariate and multivariate logistic regression analyses to identify independent predictors based on MRI features and clinical indicators. Moreover, receiver operating characteristic (ROC) curve analyses were performed to assess the diagnostic performance of the prediction model and each independent predictor. Results Among the 111 included patients, 85 were men (76.6%). Patient age was 31–86 years (average age, 61.08 ± 11.50 years). After the first treatment session, 56/111 (50.5%) patients showed an objective response (complete response + partial response), whereas the remaining showed non-response (stable disease + local progressive disease). In the univariate analysis, we identified irregular margins, number of nodules, and satellite nodules as predictors of early objective response. However, in the multivariate logistic regression analysis, irregular margins, number of nodules and pretreatment platelet were identified as the independent predictors of early objective response. A combined prediction model was then established, which factored in irregular margins, the number of nodules, and the pretreatment platelet count. This model showed good diagnostic performance (area under the ROC curve = 0.755), with the sensitivity, specificity, positive predictive value, and negative predictive value being 78.6%, 69.1%, 72.1%, and 76.0%, respectively. Conclusions Irregular margins, the number of ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s12880-022-00900-8 |
| DOI: | 10.1186/s12880-022-00900-8.pdf |
| DOI: | 10.1186/s12880-022-00900-8/fulltext.html |
| الاتاحة: | http://dx.doi.org/10.1186/s12880-022-00900-8 https://link.springer.com/content/pdf/10.1186/s12880-022-00900-8.pdf https://link.springer.com/article/10.1186/s12880-022-00900-8/fulltext.html |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.E47B9AA1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12880-022-00900-8 |
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