Academic Journal
Characterization of goat prions demonstrates geographical variation of scrapie strains in Europe and reveals the composite nature of prion strains
| العنوان: | Characterization of goat prions demonstrates geographical variation of scrapie strains in Europe and reveals the composite nature of prion strains |
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| المؤلفون: | Nonno, R, Marin-Moreno, A, Espinosa, JC, Fast, C, Van Keulen, L, Spiropoulos, J, Lantier, I, Andreoletti, O, Pirisinu, L, Di Bari, MA, Aguilar-Calvo, P, Sklaviadis, T, Papasavva-Stylianou, P, Acutis, PL, Acin, C, Bossers, A, Jacobs, JG, Vaccari, G, D''Agostino, C, Chiappini, B, Lantier, F, Groschup, MH, Agrimi, U, Torres, JM, Langeveld, JPM |
| سنة النشر: | 2020 |
| المجموعة: | Digital Repository of University of Zaragoza (ZAGUAN) |
| الوصف: | Bovine Spongiform Encephalopathy (BSE) is the only animal prion which has been recognized as a zoonotic agent so far. The identification of BSE in two goats raised the need to reliably identify BSE in small ruminants. However, our understanding of scrapie strain diversity in small ruminants remains ill-defined, thus limiting the accuracy of BSE surveillance and spreading fear that BSE might lurk unrecognized in goats. We investigated prion strain diversity in a large panel of European goats by a novel experimental approach that, instead of assessing the neuropathological profile after serial transmissions in a single animal model, was based on the direct interaction of prion isolates with several recipient rodent models expressing small ruminants or heterologous prion proteins. The findings show that the biological properties of scrapie isolates display different patterns of geographical distribution in Europe and suggest that goat BSE could be reliably discriminated from a wide range of biologically and geographically diverse goat prion isolates. Finally, most field prion isolates showed composite strain features, with discrete strain components or sub-strains being present in different proportions in individual goats or tissues. This has important implications for understanding the nature and evolution of scrapie strains and their transmissibility to other species, including humans. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | info:eu-repo/grantAgreement/EC/FP6/36353/EU/Goat BSE: proposal for improvement of goat TSE discriminative diagnosis and susceptibility based assessment of BSE infectivity in goat milk and meat/GOATBSE; info:eu-repo/grantAgreement/ES/INIA/FPI-SGIT-2015-02; info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/AGL2016-78054-R; info:eu-repo/grantAgreement/ES/MCIU/AGL2012-37988-C04-04; info:eu-repo/grantAgreement/ES/MINECO/BES-2010-040922; http://zaguan.unizar.es/record/95868 |
| DOI: | 10.1038/s41598-019-57005-6 |
| الاتاحة: | http://zaguan.unizar.es/record/95868 https://doi.org/10.1038/s41598-019-57005-6 |
| Rights: | by ; http://creativecommons.org/licenses/by/3.0/es/ |
| رقم الانضمام: | edsbas.E4758B8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-019-57005-6 |
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